ENSCHAP00000016956 protein (Clupea harengus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSCHAP00000016956

Matrix metallopeptidase 25b. (573 aa)

Predicted Functional Partners:

ENSCHAP00000035186

0.846

TIMP3

0.796

ENSCHAP00000003156

0.662

ENSCHAP00000008564

0.662

ENSCHAP00000012495

0.662

ENSCHAP00000053830

0.662

tnr

0.662

timp4

0.635

ENSCHAP00000004362

0.623

ENSCHAP00000029637

0.566

Your Current Organism:

Clupea harengus

NCBI taxonomy Id: 7950
Other names: Atlantic herring, C. harengus, Clupea harengus harengus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCHAP00000003156	ENSCHAP00000004362	ENSCHAP00000003156	ENSCHAP00000004362	annotation not available	Matrix metallopeptidase 14b (membrane-inserted).	0.666
ENSCHAP00000003156	ENSCHAP00000008564	ENSCHAP00000003156	ENSCHAP00000008564	annotation not available	Zmp:0000000846.	0.632
ENSCHAP00000003156	ENSCHAP00000012495	ENSCHAP00000003156	ENSCHAP00000012495	annotation not available	annotation not available	0.984
ENSCHAP00000003156	ENSCHAP00000016956	ENSCHAP00000003156	ENSCHAP00000016956	annotation not available	Matrix metallopeptidase 25b.	0.662
ENSCHAP00000003156	ENSCHAP00000053830	ENSCHAP00000003156	ENSCHAP00000053830	annotation not available	Tenascin N.	0.824
ENSCHAP00000003156	tnr	ENSCHAP00000003156	ENSCHAP00000055355	annotation not available	Tenascin R.	0.848
ENSCHAP00000004362	ENSCHAP00000003156	ENSCHAP00000004362	ENSCHAP00000003156	Matrix metallopeptidase 14b (membrane-inserted).	annotation not available	0.666
ENSCHAP00000004362	ENSCHAP00000008564	ENSCHAP00000004362	ENSCHAP00000008564	Matrix metallopeptidase 14b (membrane-inserted).	Zmp:0000000846.	0.666
ENSCHAP00000004362	ENSCHAP00000012495	ENSCHAP00000004362	ENSCHAP00000012495	Matrix metallopeptidase 14b (membrane-inserted).	annotation not available	0.662
ENSCHAP00000004362	ENSCHAP00000016956	ENSCHAP00000004362	ENSCHAP00000016956	Matrix metallopeptidase 14b (membrane-inserted).	Matrix metallopeptidase 25b.	0.623
ENSCHAP00000004362	ENSCHAP00000029637	ENSCHAP00000004362	ENSCHAP00000029637	Matrix metallopeptidase 14b (membrane-inserted).	annotation not available	0.717
ENSCHAP00000004362	ENSCHAP00000035186	ENSCHAP00000004362	ENSCHAP00000035186	Matrix metallopeptidase 14b (membrane-inserted).	TIMP metallopeptidase inhibitor 2a.	0.992
ENSCHAP00000004362	ENSCHAP00000053830	ENSCHAP00000004362	ENSCHAP00000053830	Matrix metallopeptidase 14b (membrane-inserted).	Tenascin N.	0.662
ENSCHAP00000004362	TIMP3	ENSCHAP00000004362	ENSCHAP00000054521	Matrix metallopeptidase 14b (membrane-inserted).	TIMP metallopeptidase inhibitor 3.	0.860
ENSCHAP00000004362	timp4	ENSCHAP00000004362	ENSCHAP00000036877	Matrix metallopeptidase 14b (membrane-inserted).	TIMP metallopeptidase inhibitor 4.	0.758
ENSCHAP00000004362	tnr	ENSCHAP00000004362	ENSCHAP00000055355	Matrix metallopeptidase 14b (membrane-inserted).	Tenascin R.	0.662
ENSCHAP00000008564	ENSCHAP00000003156	ENSCHAP00000008564	ENSCHAP00000003156	Zmp:0000000846.	annotation not available	0.632
ENSCHAP00000008564	ENSCHAP00000004362	ENSCHAP00000008564	ENSCHAP00000004362	Zmp:0000000846.	Matrix metallopeptidase 14b (membrane-inserted).	0.666
ENSCHAP00000008564	ENSCHAP00000012495	ENSCHAP00000008564	ENSCHAP00000012495	Zmp:0000000846.	annotation not available	0.809
ENSCHAP00000008564	ENSCHAP00000016956	ENSCHAP00000008564	ENSCHAP00000016956	Zmp:0000000846.	Matrix metallopeptidase 25b.	0.662

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.878

expected number of edges:

13

PPI enrichment p-value:

1.85e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0021577

Hindbrain structural organization

5 of 7

3.26

6.11

6.72e-12

GO:1903895

Negative regulation of IRE1-mediated unfolded protein response

5 of 10

3.11

5.92

1.27e-11

GO:0031204

Post-translational protein targeting to membrane, translocation

5 of 10

3.11

5.92

1.27e-11

GO:0006983

ER overload response

5 of 11

3.07

5.88

1.39e-11

GO:0035437

Maintenance of protein localization in endoplasmic reticulum

5 of 16

2.9

5.58

3.69e-11

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140662

ATP-dependent protein folding chaperone

10 of 36

2.85

12.13

7.01e-25

GO:0044183

Protein folding chaperone

11 of 65

2.64

11.79

7.01e-26

GO:0051787

Misfolded protein binding

7 of 33

2.73

7.54

1.98e-15

GO:0043022

Ribosome binding

5 of 75

2.23

3.72

2.23e-08

GO:0031625

Ubiquitin protein ligase binding

6 of 212

1.86

3.16

2.42e-08

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034663

Endoplasmic reticulum chaperone complex

5 of 8

3.2

6.16

5.09e-12

GO:0005793

Endoplasmic reticulum-Golgi intermediate compartment

5 of 75

2.23

3.59

4.69e-08

GO:0042470

Melanosome

5 of 88

2.16

3.45

6.75e-08

GO:0005788

Endoplasmic reticulum lumen

5 of 89

2.16

3.44

6.75e-08

GO:0030176

Integral component of endoplasmic reticulum membrane

5 of 132

1.99

3.04

2.06e-07

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37761919

(2023) Hsp70 Gene Family in Sebastiscus marmoratus: The Genome-Wide Identification and Transcriptome Analysis under Thermal Stress.

4 of 10

3.01

3.94

6.01e-08

PMID:33150058

(2020) Genome-wide identification of Hsp70110 genes in rainbow trout and their regulated expression in response to heat stress.

3 of 9

2.93

2.61

1.74e-05

PMID:30501106

(2018) Genome-Wide Identification of Hsp70 Genes in the Large Yellow Croaker (Larimichthys crocea) and Their Regulated Expression Under Cold and Heat Stress.

3 of 8

2.98

2.61

1.74e-05

PMID:34880782

(2021) HSP90 and HSP70 Families in Lateolabrax maculatus: Genome-Wide Identification, Molecular Characterization, and Expression Profiles in Response to Various Environmental Stressors.

2 of 8

2.81

1.23

0.0060

PMID:30691127

(2019) The Hsp70 Gene Family in Boleophthalmus pectinirostris: Genome-Wide Identification and Expression Analysis under High Ammonia Stress.

2 of 7

2.86

1.23

0.0060

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10359

Protein folding, and Conjugation with cellular fusion

11 of 79

2.55

10.96

1.09e-24

CL:10366

Mixed, incl. Misfolded protein binding, and Chaperone DnaJ, C-terminal

9 of 59

2.59

9.25

5.66e-20

CL:10448

Mixed, incl. Endoplasmic reticulum chaperone complex, and Protein folding in endoplasmic reticulum

5 of 15

2.93

5.7

2.33e-11

CL:10370

Mixed, incl. Protein refolding, and DnaJ C terminal domain

4 of 34

2.48

3.33

4.10e-07

CL:10467

Hindbrain structural organization, and Calreticulin family

3 of 5

3.19

3.32

9.55e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

onl03060

Protein export

3 of 22

2.54

2.7

8.43e-06

onl04141

Protein processing in endoplasmic reticulum

5 of 179

1.85

2.65

8.39e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3371453

Regulation of HSF1-mediated heat shock response

11 of 98

2.46

10.35

2.90e-24

MAP-3371556

Cellular response to heat stress

11 of 157

2.25

8.67

2.04e-22

MAP-983170

Antigen Presentation: Folding, assembly and peptide loading of class I MHC

5 of 84

2.18

3.55

4.27e-08

MAP-2262752

Cellular responses to stress

11 of 878

1.51

3.19

1.63e-14

MAP-8953897

Cellular responses to stimuli

11 of 889

1.5

3.17

1.63e-14

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0067

ATP-binding

6 of 982

1.19

1.15

0.00024

KW-0175

Coiled coil

8 of 3711

0.74

0.6

0.0012

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF06723

MreB/Mbl protein

8 of 15

3.13

10.5

1.96e-20

PF00012

Hsp70 protein

4 of 7

3.16

4.55

4.94e-09

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029047

Heat shock protein 70kD, peptide-binding domain superfamily

7 of 10

3.25

9.12

1.41e-17

IPR013126

Heat shock protein 70 family

7 of 13

3.14

8.89

2.80e-17

IPR018181

Heat shock protein 70, conserved site

6 of 10

3.19

7.57

1.09e-14

IPR043129

ATPase, nucleotide binding domain

7 of 49

2.56

6.67

4.17e-14

IPR029048

Heat shock protein 70kD, C-terminal domain superfamily

5 of 9

3.15

6.05

7.64e-12

(more ...)

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