ENSCHAP00000041395 protein (Clupea harengus)

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ENSCHAP00000041395

Family with sequence similarity 149 member A. (842 aa)

Predicted Functional Partners:

gne

0.794

gm2a

0.749

pigv

0.740

ENSCHAP00000039826

0.740

ENSCHAP00000003796

0.738

alg3

0.723

ENSCHAP00000029970

0.715

ENSCHAP00000011995

0.698

ENSCHAP00000027480

0.675

ENSCHAP00000000560

0.674

Your Current Organism:

Clupea harengus

NCBI taxonomy Id: 7950
Other names: Atlantic herring, C. harengus, Clupea harengus harengus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCHAP00000000560	ENSCHAP00000041395	ENSCHAP00000000560	ENSCHAP00000041395	Chitinase, acidic.3.	Family with sequence similarity 149 member A.	0.674
ENSCHAP00000000560	gne	ENSCHAP00000000560	ENSCHAP00000041283	Chitinase, acidic.3.	Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase.	0.610
ENSCHAP00000003796	ENSCHAP00000011995	ENSCHAP00000003796	ENSCHAP00000011995	beta-1,4-N-acetyl-galactosaminyl transferase 1a.	ST3 beta-galactoside alpha-2,3-sialyltransferase 7.	0.854
ENSCHAP00000003796	ENSCHAP00000029970	ENSCHAP00000003796	ENSCHAP00000029970	beta-1,4-N-acetyl-galactosaminyl transferase 1a.	ST3 beta-galactoside alpha-2,3-sialyltransferase 5.	0.888
ENSCHAP00000003796	ENSCHAP00000041395	ENSCHAP00000003796	ENSCHAP00000041395	beta-1,4-N-acetyl-galactosaminyl transferase 1a.	Family with sequence similarity 149 member A.	0.738
ENSCHAP00000011995	ENSCHAP00000003796	ENSCHAP00000011995	ENSCHAP00000003796	ST3 beta-galactoside alpha-2,3-sialyltransferase 7.	beta-1,4-N-acetyl-galactosaminyl transferase 1a.	0.854
ENSCHAP00000011995	ENSCHAP00000029970	ENSCHAP00000011995	ENSCHAP00000029970	ST3 beta-galactoside alpha-2,3-sialyltransferase 7.	ST3 beta-galactoside alpha-2,3-sialyltransferase 5.	0.859
ENSCHAP00000011995	ENSCHAP00000041395	ENSCHAP00000011995	ENSCHAP00000041395	ST3 beta-galactoside alpha-2,3-sialyltransferase 7.	Family with sequence similarity 149 member A.	0.698
ENSCHAP00000027480	ENSCHAP00000041395	ENSCHAP00000027480	ENSCHAP00000041395	Glucuronidase, beta.	Family with sequence similarity 149 member A.	0.675
ENSCHAP00000027480	gne	ENSCHAP00000027480	ENSCHAP00000041283	Glucuronidase, beta.	Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase.	0.919
ENSCHAP00000029970	ENSCHAP00000003796	ENSCHAP00000029970	ENSCHAP00000003796	ST3 beta-galactoside alpha-2,3-sialyltransferase 5.	beta-1,4-N-acetyl-galactosaminyl transferase 1a.	0.888
ENSCHAP00000029970	ENSCHAP00000011995	ENSCHAP00000029970	ENSCHAP00000011995	ST3 beta-galactoside alpha-2,3-sialyltransferase 5.	ST3 beta-galactoside alpha-2,3-sialyltransferase 7.	0.859
ENSCHAP00000029970	ENSCHAP00000041395	ENSCHAP00000029970	ENSCHAP00000041395	ST3 beta-galactoside alpha-2,3-sialyltransferase 5.	Family with sequence similarity 149 member A.	0.715
ENSCHAP00000039826	ENSCHAP00000041395	ENSCHAP00000039826	ENSCHAP00000041395	Phosphatidylinositol glycan anchor biosynthesis, class B.	Family with sequence similarity 149 member A.	0.740
ENSCHAP00000039826	alg3	ENSCHAP00000039826	ENSCHAP00000030042	Phosphatidylinositol glycan anchor biosynthesis, class B.	ALG3 alpha-1,3- mannosyltransferase.	0.905
ENSCHAP00000039826	pigv	ENSCHAP00000039826	ENSCHAP00000023485	Phosphatidylinositol glycan anchor biosynthesis, class B.	Phosphatidylinositol glycan anchor biosynthesis class V.	0.938
ENSCHAP00000041395	ENSCHAP00000000560	ENSCHAP00000041395	ENSCHAP00000000560	Family with sequence similarity 149 member A.	Chitinase, acidic.3.	0.674
ENSCHAP00000041395	ENSCHAP00000003796	ENSCHAP00000041395	ENSCHAP00000003796	Family with sequence similarity 149 member A.	beta-1,4-N-acetyl-galactosaminyl transferase 1a.	0.738
ENSCHAP00000041395	ENSCHAP00000011995	ENSCHAP00000041395	ENSCHAP00000011995	Family with sequence similarity 149 member A.	ST3 beta-galactoside alpha-2,3-sialyltransferase 7.	0.698
ENSCHAP00000041395	ENSCHAP00000027480	ENSCHAP00000041395	ENSCHAP00000027480	Family with sequence similarity 149 member A.	Glucuronidase, beta.	0.675

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Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007017

Microtubule-based process

8 of 721

1.33

1.67

3.08e-06

GO:0010970

Transport along microtubule

4 of 115

1.83

1.36

0.0017

GO:0032402

Melanosome transport

2 of 11

2.55

0.8

0.0349

GO:1902850

Microtubule cytoskeleton organization involved in mitosis

3 of 109

1.73

0.75

0.0349

GO:0051650

Establishment of vesicle localization

3 of 122

1.68

0.74

0.0349

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005869

Dynactin complex

6 of 15

2.89

6.79

1.52e-13

GO:0005875

Microtubule associated complex

9 of 144

2.08

5.8

3.45e-15

GO:0030286

Dynein complex

4 of 58

2.13

2.63

4.76e-06

GO:0005813

Centrosome

8 of 554

1.45

2.28

1.36e-08

GO:0000776

Kinetochore

4 of 127

1.78

1.88

7.64e-05

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36107127

(2022) Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin.

6 of 9

3.11

6.48

1.08e-12

PMID:36071160

(2022) Structure of dynein-dynactin on microtubules shows tandem adaptor binding.

3 of 9

2.81

1.81

0.00051

PMID:33734450

(2021) Cryo-EM reveals the complex architecture of dynactins shoulder region and pointed end.

3 of 8

2.86

1.81

0.00051

PMID:18437411

(2008) The mammalian centrosome and its functional significance.

3 of 18

2.51

1.45

0.0021

PMID:33523880

(2021) The Arp111 minifilament of dynactin primes the endosomal Arp23 complex.

3 of 22

2.42

1.38

0.0028

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15025

Cytoplasmic dynein complex, and Dynactin complex

11 of 33

2.81

13.02

3.35e-27

CL:15064

Dynactin complex, and F-actin-capping protein subunit alpha/beta

9 of 12

3.16

12.32

5.81e-24

CL:15067

Dynactin complex

7 of 7

3.29

9.61

1.83e-18

CL:15029

Mixed, incl. Dynein light chain, type 1/2, conserved site, and Dynein family light intermediate chain

2 of 7

2.74

1.28

0.0048

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ssc04962

Vasopressin-regulated water reabsorption

7 of 39

2.54

6.83

1.47e-14

ssc05016

Huntington disease

7 of 260

1.72

3.12

2.35e-09

ssc05014

Amyotrophic lateral sclerosis

7 of 306

1.65

2.87

4.79e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

SSC-6811436

COPI-independent Golgi-to-ER retrograde traffic

10 of 39

2.7

10.96

2.74e-23

SSC-3371497

HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand

10 of 40

2.68

10.92

2.74e-23

SSC-6807878

COPI-mediated anterograde transport

10 of 80

2.38

8.85

6.35e-21

SSC-2132295

MHC class II antigen presentation

10 of 119

2.21

7.6

1.63e-19

SSC-380259

Loss of Nlp from mitotic centrosomes

6 of 60

2.29

4.97

3.20e-11

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005869

Dynactin complex

6 of 7

3.22

7.72

6.14e-15

GOCC:0005875

Microtubule associated complex

9 of 123

2.15

6.2

1.12e-15

GOCC:0015630

Microtubule cytoskeleton

10 of 593

1.51

3.0

2.21e-12

GOCC:0030286

Dynein complex

4 of 57

2.13

2.62

4.97e-06

GOCC:0005868

Cytoplasmic dynein complex

2 of 18

2.33

1.08

0.0102

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00132

Bacterial transferase hexapeptide (six repeats)

2 of 4

2.99

1.16

0.0081

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR011004

Trimeric LpxA-like superfamily

2 of 4

2.99

0.91

0.0225

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