abat protein (Clupea harengus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Gene Fusion

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[Homology]

Score

abat

4-aminobutyrate aminotransferase. (504 aa)

Predicted Functional Partners:

ENSCHAP00000022172

0.958

sgpl1

0.942

ENSCHAP00000000610

0.920

aldh16a1

0.920

LOC105898664

0.920

ENSCHAP00000046252

0.920

LOC105897198

0.920

ENSCHAP00000060931

0.920

ENSCHAP00000051223

0.918

aldh7a1

0.917

Your Current Organism:

Clupea harengus

NCBI taxonomy Id: 7950
Other names: Atlantic herring, C. harengus, Clupea harengus harengus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCHAP00000000610	ENSCHAP00000022172	ENSCHAP00000000610	ENSCHAP00000022172	Aldehyde dehydrogenase 3 family, member A2b.	Aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase).	0.781
ENSCHAP00000000610	ENSCHAP00000046252	ENSCHAP00000000610	ENSCHAP00000046252	Aldehyde dehydrogenase 3 family, member A2b.	Aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 1.	0.558
ENSCHAP00000000610	ENSCHAP00000051223	ENSCHAP00000000610	ENSCHAP00000051223	Aldehyde dehydrogenase 3 family, member A2b.	Alanine--glyoxylate aminotransferase 2.	0.912
ENSCHAP00000000610	LOC105897198	ENSCHAP00000000610	ENSCHAP00000060839	Aldehyde dehydrogenase 3 family, member A2b.	Fatty aldehyde dehydrogenase-like.	0.765
ENSCHAP00000000610	abat	ENSCHAP00000000610	ENSCHAP00000048363	Aldehyde dehydrogenase 3 family, member A2b.	4-aminobutyrate aminotransferase.	0.920
ENSCHAP00000000610	aldh16a1	ENSCHAP00000000610	ENSCHAP00000039414	Aldehyde dehydrogenase 3 family, member A2b.	Aldehyde dehydrogenase 16 family member A1.	0.810
ENSCHAP00000000610	aldh7a1	ENSCHAP00000000610	ENSCHAP00000048473	Aldehyde dehydrogenase 3 family, member A2b.	Aldehyde dehydrogenase 7 family member A1.	0.749
ENSCHAP00000000610	sgpl1	ENSCHAP00000000610	ENSCHAP00000008614	Aldehyde dehydrogenase 3 family, member A2b.	Sphingosine-1-phosphate lyase 1.	0.751
ENSCHAP00000022172	ENSCHAP00000000610	ENSCHAP00000022172	ENSCHAP00000000610	Aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase).	Aldehyde dehydrogenase 3 family, member A2b.	0.781
ENSCHAP00000022172	ENSCHAP00000046252	ENSCHAP00000022172	ENSCHAP00000046252	Aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase).	Aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 1.	0.703
ENSCHAP00000022172	ENSCHAP00000051223	ENSCHAP00000022172	ENSCHAP00000051223	Aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase).	Alanine--glyoxylate aminotransferase 2.	0.927
ENSCHAP00000022172	ENSCHAP00000060931	ENSCHAP00000022172	ENSCHAP00000060931	Aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase).	Aldehyde dehydrogenase 3 family, member A2a.	0.781
ENSCHAP00000022172	LOC105897198	ENSCHAP00000022172	ENSCHAP00000060839	Aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase).	Fatty aldehyde dehydrogenase-like.	0.781
ENSCHAP00000022172	LOC105898664	ENSCHAP00000022172	ENSCHAP00000040243	Aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase).	Aldehyde dehydrogenase family 3 member B1-like.	0.781
ENSCHAP00000022172	abat	ENSCHAP00000022172	ENSCHAP00000048363	Aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase).	4-aminobutyrate aminotransferase.	0.958
ENSCHAP00000022172	aldh16a1	ENSCHAP00000022172	ENSCHAP00000039414	Aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase).	Aldehyde dehydrogenase 16 family member A1.	0.704
ENSCHAP00000022172	aldh7a1	ENSCHAP00000022172	ENSCHAP00000048473	Aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase).	Aldehyde dehydrogenase 7 family member A1.	0.866
ENSCHAP00000022172	sgpl1	ENSCHAP00000022172	ENSCHAP00000008614	Aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase).	Sphingosine-1-phosphate lyase 1.	0.941
ENSCHAP00000046252	ENSCHAP00000000610	ENSCHAP00000046252	ENSCHAP00000000610	Aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 1.	Aldehyde dehydrogenase 3 family, member A2b.	0.558
ENSCHAP00000046252	ENSCHAP00000022172	ENSCHAP00000046252	ENSCHAP00000022172	Aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 1.	Aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase).	0.703

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006810

Transport

11 of 466

0.86

0.91

4.39e-07

GO:0055085

Transmembrane transport

9 of 414

0.82

0.76

8.29e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005215

Transporter activity

10 of 391

0.89

0.93

3.12e-06

GO:0005524

ATP binding

8 of 337

0.86

0.74

0.00043

GO:0022857

Transmembrane transporter activity

8 of 386

0.8

0.68

0.00043

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

11 of 563

0.78

0.79

3.96e-07

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4556

MacB, ATP-binding domain, and FtsX-like permease family

10 of 18

2.23

7.36

2.04e-18

CL:4558

FtsX-like permease family, and ABC transporter, lipoprotein release, LolD-like

8 of 13

2.27

6.22

1.48e-14

CL:4561

FtsX-like permease family

5 of 6

2.41

4.15

6.10e-09

CL:4336

ABC transporters, and Metal ion transmembrane transporter activity

11 of 166

1.31

2.28

9.04e-13

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02010

ABC transporters

10 of 189

1.21

1.8

4.84e-10

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0098796

Membrane protein complex

4 of 72

1.23

0.82

0.0086

GOCC:0016020

Membrane

11 of 580

0.76

1.09e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0997

Cell inner membrane

5 of 6

2.41

4.03

1.08e-08

KW-0046

Antibiotic resistance

5 of 9

2.23

3.79

1.56e-08

KW-1278

Translocase

5 of 17

1.95

3.08

1.21e-07

KW-0067

ATP-binding

10 of 271

1.05

1.34

1.32e-08

KW-1003

Cell membrane

6 of 182

1.0

0.91

0.00031

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12704

MacB-like periplasmic core domain

6 of 7

2.42

4.85

1.81e-10

PF02687

FtsX-like permease family

6 of 9

2.31

4.63

2.64e-10

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017911

MacB, ATP-binding domain

10 of 10

2.48

8.93

4.91e-20

IPR025857

MacB-like periplasmic core domain

6 of 7

2.42

4.97

9.66e-11

IPR003838

ABC3 transporter permease protein domain

6 of 9

2.31

4.65

2.34e-10

IPR003439

ABC transporter-like, ATP-binding domain

10 of 82

1.57

3.26

9.39e-13

IPR017871

ABC transporter-like, conserved site

9 of 70

1.59

3.15

2.22e-11

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00382

ATPases associated with a variety of cellular activities

10 of 105

1.46

2.83

1.64e-12

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