STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSCHAP00000062650Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (124 aa)    
Predicted Functional Partners:
ENSCHAP00000010851
MDM2 proto-oncogene.
   
 0.995
ENSCHAP00000003889
MDM4 regulator of p53.
   
 0.974
ENSCHAP00000037520
Cyclin-dependent kinase 4.
    
 0.957
ENSCHAP00000039408
Tumor protein p53.
    
 0.954
ENSCHAP00000033815
Cyclin-dependent kinase 6.
    
 0.947
ENSCHAP00000039357
Tumor protein p53.
    
 0.942
ENSCHAP00000042143
annotation not available
    
 0.942
CCND1
Cyclin D1.
    
 0.926
ccnd2
Cyclin D2.
    
 0.926
ENSCHAP00000040485
Cyclin-dependent kinase 2.
    
 0.894
Your Current Organism:
Clupea harengus
NCBI taxonomy Id: 7950
Other names: Atlantic herring, C. harengus, Clupea harengus harengus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.