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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnaAChromosomal replication initiator protein dnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (448 aa)    
Predicted Functional Partners:
AEH23563.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
 
 
 0.982
AEH23159.1
PFAM: Protein of unknown function DUF214, permase predicted; KEGG: vpr:Vpar_1070 protein of unknown function DUF214.
 
      0.900
AEH23160.1
Phosphonate-transporting ATPase; PFAM: ABC transporter-like; KEGG: cbf:CLI_0142 putative macrolide efflux ABC transporter, ATP-binding protein; SMART: ATPase, AAA+ type, core.
      0.899
AEH22119.1
D-lactate dehydrogenase (cytochrome); KEGG: glo:Glov_0464 FAD linked oxidase domain protein; PFAM: FAD linked oxidase, N-terminal; FAD-linked oxidase, C-terminal.
       0.816
AEH22483.1
CoA-disulfide reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: dps:DP2890 NADH oxidase; SMART: Rhodanese-like.
  
    0.797
AEH22120.1
PP-loop domain protein; PFAM: PP-loop; KEGG: dal:Dalk_1237 PP-loop domain protein; Belongs to the TtcA family.
     
 0.761
AEH22302.1
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.
   
 
 0.761
AEH22337.1
PFAM: Cobyrinic acid a,c-diamide synthase; KEGG: fjo:Fjoh_0202 cobyrinic acid a,c-diamide synthase.
 
 
 0.708
rnpA
Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
  
  
 0.656
AEH22935.1
KEGG: ddf:DEFDS_1930 phosphatase Ppx/GppA family; PFAM: Ppx/GppA phosphatase; Histone-like bacterial DNA-binding protein; SMART: Histone-like bacterial DNA-binding protein.
   
 
 0.612
Your Current Organism:
Thermodesulfobacterium geofontis
NCBI taxonomy Id: 795359
Other names: T. geofontis OPF15, Thermodesulfobacterium geofontis OPF15, Thermodesulfobacterium sp. OPF15
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