Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-expression
Experiments
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[Homology]
Score
AEH22187.1Protein of unknown function UPF0118; PFAM: Uncharacterised protein family UPF0118; KEGG: aae:aq_740 hypothetical protein. (350 aa)    
Predicted Functional Partners:
AEH22186.1
TIGRFAM: DNA glycosylase/AP lyase; KEGG: adg:Adeg_1023 formamidopyrimidine-DNA glycosylase; PFAM: DNA glycosylase/AP lyase, catalytic domain; DNA glycosylase/AP lyase, H2TH DNA-binding.
       0.811
AEH22189.1
PFAM: Protein of unknown function DUF1844; KEGG: sfu:Sfum_3650 hypothetical protein.
 
     0.612
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
       0.558
AEH22188.1
TIGRFAM: Regulatory protein, FmdB, putative; PFAM: Regulatory protein, FmdB, putative; KEGG: dth:DICTH_1607 putative regulatory protein, FmdB family.
       0.536
ispE
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
       0.535
AEH22185.1
Histone family protein DNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
       0.518
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
       0.512
rplY
50S ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
     
 0.470
pth
Peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.
       0.464
AEH22197.1
PFAM: Amino acid-binding ACT; KEGG: dau:Daud_0194 beta-lactamase domain-containing protein.
  
    0.456
Your Current Organism:
Thermodesulfobacterium geofontis
NCBI taxonomy Id: 795359
Other names: T. geofontis OPF15, Thermodesulfobacterium geofontis OPF15, Thermodesulfobacterium sp. OPF15
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