Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AEH22477.1PFAM: Myo-inositol-1-phosphate synthase; Myo-inositol-1-phosphate synthase, GAPDH-like; KEGG: hth:HTH_1533 myo-inositol-1-phosphate synthase. (368 aa)    
Predicted Functional Partners:
AEH22730.1
PFAM: Inositol monophosphatase; NUDIX hydrolase domain; KEGG: dak:DaAHT2_0139 inositol monophosphatase.
   
 
 0.914
AEH22329.1
PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain III; Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; Alpha-D-phosphohexomutase, C-terminal; KEGG: sat:SYN_00938 phosphomannomutase.
     
  0.900
AEH22515.1
Glucokinase; KEGG: plu:plu1405 glucokinase; PFAM: Glucokinase; Belongs to the bacterial glucokinase family.
     
  0.900
AEH22476.1
TIGRFAM: LL-diaminopimelate aminotransferase; KEGG: hya:HY04AAS1_0487 LL-diaminopimelate aminotransferase; PFAM: Aminotransferase, class I/II.
  
    0.815
AEH22475.1
PFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; manually curated; KEGG: tye:THEYE_A1015 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK.
       0.779
AEH22474.1
YHS domain-containing protein; PFAM: YHS; SMART: TRASH; KEGG: ddf:DEFDS_0351 hypothetical protein.
       0.773
AEH22980.1
PFAM: CDP-alcohol phosphatidyltransferase; KEGG: atm:ANT_09900 putative phosphatidylinositol synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
 
   
 0.761
AEH22483.1
CoA-disulfide reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: dps:DP2890 NADH oxidase; SMART: Rhodanese-like.
     
 0.596
gyrA
DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
       0.591
AEH22480.1
TIGRFAM: Glutamine amidotransferase of anthranilate synthase; KEGG: nmu:Nmul_A2564 glutamine amidotransferase of anthranilate synthase or para-aminobenzoate synthase; PFAM: Glutamine amidotransferase class-I, C-terminal.
       0.589
Your Current Organism:
Thermodesulfobacterium geofontis
NCBI taxonomy Id: 795359
Other names: T. geofontis OPF15, Thermodesulfobacterium geofontis OPF15, Thermodesulfobacterium sp. OPF15
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.