STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEH22500.1PFAM: Methylenetetrahydrofolate reductase; KEGG: adg:Adeg_0345 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (306 aa)    
Predicted Functional Partners:
AEH22499.1
PFAM: CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel; KEGG: dak:DaAHT2_0826 CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel.
   
 0.989
AEH22497.1
PFAM: CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel; Putative Fe-S cluster; Dihydropteroate synthase, DHPS; KEGG: dak:DaAHT2_0824 CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel.
 
  
 0.977
folD
Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.976
AEH22501.1
KEGG: dal:Dalk_2780 hypothetical protein.
 
  
 0.959
AEH23396.1
KEGG: dal:Dalk_5194 hypothetical protein.
 
 
 0.950
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.943
AEH22498.1
TIGRFAM: CO dehydrogenase/acetyl-CoA synthase complex beta subunit; KEGG: dak:DaAHT2_0825 CO dehydrogenase/acetyl-CoA synthase complex, beta subunit; PFAM: CO dehydrogenase/acetyl-CoA synthase complex beta subunit.
 
   
 0.936
AEH22404.1
KEGG: deg:DehalGT_0699 thymidylate synthase, putative.
     
 0.927
AEH22502.1
KEGG: adg:Adeg_0335 carbon-monoxide dehydrogenase, catalytic subunit; PFAM: Prismane.
 
   
 0.914
fhs
HAMAP: Formate-tetrahydrofolate ligase, FTHFS; KEGG: dak:DaAHT2_0837 formate--tetrahydrofolate ligase; PFAM: Formate-tetrahydrofolate ligase, FTHFS; Belongs to the formate--tetrahydrofolate ligase family.
  
  
 0.766
Your Current Organism:
Thermodesulfobacterium geofontis
NCBI taxonomy Id: 795359
Other names: T. geofontis OPF15, Thermodesulfobacterium geofontis OPF15, Thermodesulfobacterium sp. OPF15
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