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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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folDBifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (300 aa)    
Predicted Functional Partners:
fhs
HAMAP: Formate-tetrahydrofolate ligase, FTHFS; KEGG: dak:DaAHT2_0837 formate--tetrahydrofolate ligase; PFAM: Formate-tetrahydrofolate ligase, FTHFS; Belongs to the formate--tetrahydrofolate ligase family.
 
 0.998
AEH22500.1
PFAM: Methylenetetrahydrofolate reductase; KEGG: adg:Adeg_0345 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
    
 0.976
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.974
AEH22143.1
Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dak:DaAHT2_1420 IMP cyclohydrolase; SMART: AICARFT/IMPCHase bienzyme, formylation region.
 
 
 0.955
AEH22777.1
KEGG: nth:Nther_2750 glycine cleavage system H protein; HAMAP: Glycine cleavage H-protein; PFAM: Glycine cleavage H-protein.
  
 
 0.952
AEH23583.1
Phosphoribosylaminoimidazolecarboxamide formyltransferase; KEGG: dte:Dester_0983 bifunctional purine biosynthesis protein PurH; PFAM: MGS-like; AICARFT/IMPCHase bienzyme, formylation region.
  
 
 0.949
AEH22404.1
KEGG: deg:DehalGT_0699 thymidylate synthase, putative.
  
 
 0.942
AEH23622.1
5-formyltetrahydrofolate cyclo-ligase; KEGG: dth:DICTH_1097 5,10-methenyltetrahydrofolate synthetase; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase.
    
 0.923
fmt
Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
 
  
 0.843
AEH22508.1
KEGG: adg:Adeg_0900 formyl transferase domain protein.
 
  
 0.827
Your Current Organism:
Thermodesulfobacterium geofontis
NCBI taxonomy Id: 795359
Other names: T. geofontis OPF15, Thermodesulfobacterium geofontis OPF15, Thermodesulfobacterium sp. OPF15
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