Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEH22537.1DNA polymerase III, alpha subunit; SMART: Polymerase/histidinol phosphatase, N-terminal; TIGRFAM: DNA polymerase III, alpha subunit; KEGG: dte:Dester_1146 DNA polymerase III, alpha subunit; PFAM: Bacterial DNA polymerase III, alpha subunit; PHP, C-terminal; Nucleic acid binding, OB-fold, tRNA/helicase-type. (1142 aa)    
Predicted Functional Partners:
AEH23137.1
PFAM: DNA polymerase III, delta; KEGG: ssp:SSP1171 DNA polymerase III subunit delta.
   
 0.990
AEH23563.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 
 0.990
dnaX
DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
 
 0.984
AEH22943.1
TIGRFAM: DNA polymerase III, delta prime subunit; KEGG: aar:Acear_0044 DNA polymerase III subunit delta'.
  
 0.981
AEH22359.1
Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
   
 
 0.879
AEH22532.1
KEGG: din:Selin_2214 cell wall hydrolase/autolysin; PFAM: Cell wall hydrolase/autolysin, catalytic; Peptidoglycan-binding lysin domain; SMART: Cell wall hydrolase/autolysin, catalytic; Peptidoglycan-binding Lysin subgroup.
     
 0.686
proB
Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
       0.669
mutS
DNA mismatch repair protein mutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
     
 0.664
nadD
Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
     
 0.633
AEH22534.1
PFAM: Phosphoesterase, RecJ-like; KEGG: dak:DaAHT2_1369 phosphoesterase RecJ domain protein.
  
  
 0.632
Your Current Organism:
Thermodesulfobacterium geofontis
NCBI taxonomy Id: 795359
Other names: T. geofontis OPF15, Thermodesulfobacterium geofontis OPF15, Thermodesulfobacterium sp. OPF15
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