| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEH22680.1 | AEH22681.1 | TOPB45_0578 | TOPB45_0579 | UPF0082 protein yeeN; TIGRFAM: Protein of unknown function DUF28; HAMAP: Protein of unknown function DUF28; KEGG: adg:Adeg_1634 protein of unknown function DUF28; PFAM: Protein of unknown function DUF28. | PFAM: Protein of unknown function DUF395, YeeE/YedE; KEGG: dpr:Despr_3284 hypothetical protein. | 0.452 |
| AEH22680.1 | AEH22682.1 | TOPB45_0578 | TOPB45_0580 | UPF0082 protein yeeN; TIGRFAM: Protein of unknown function DUF28; HAMAP: Protein of unknown function DUF28; KEGG: adg:Adeg_1634 protein of unknown function DUF28; PFAM: Protein of unknown function DUF28. | 2-hydroxy-3-oxopropionate reductase; KEGG: tba:TERMP_01423 3-hydroxyisobutyrate dehydrogenase; PFAM: 6-phosphogluconate dehydrogenase, NAD-binding. | 0.471 |
| AEH22681.1 | AEH22680.1 | TOPB45_0579 | TOPB45_0578 | PFAM: Protein of unknown function DUF395, YeeE/YedE; KEGG: dpr:Despr_3284 hypothetical protein. | UPF0082 protein yeeN; TIGRFAM: Protein of unknown function DUF28; HAMAP: Protein of unknown function DUF28; KEGG: adg:Adeg_1634 protein of unknown function DUF28; PFAM: Protein of unknown function DUF28. | 0.452 |
| AEH22681.1 | AEH22682.1 | TOPB45_0579 | TOPB45_0580 | PFAM: Protein of unknown function DUF395, YeeE/YedE; KEGG: dpr:Despr_3284 hypothetical protein. | 2-hydroxy-3-oxopropionate reductase; KEGG: tba:TERMP_01423 3-hydroxyisobutyrate dehydrogenase; PFAM: 6-phosphogluconate dehydrogenase, NAD-binding. | 0.678 |
| AEH22682.1 | AEH22680.1 | TOPB45_0580 | TOPB45_0578 | 2-hydroxy-3-oxopropionate reductase; KEGG: tba:TERMP_01423 3-hydroxyisobutyrate dehydrogenase; PFAM: 6-phosphogluconate dehydrogenase, NAD-binding. | UPF0082 protein yeeN; TIGRFAM: Protein of unknown function DUF28; HAMAP: Protein of unknown function DUF28; KEGG: adg:Adeg_1634 protein of unknown function DUF28; PFAM: Protein of unknown function DUF28. | 0.471 |
| AEH22682.1 | AEH22681.1 | TOPB45_0580 | TOPB45_0579 | 2-hydroxy-3-oxopropionate reductase; KEGG: tba:TERMP_01423 3-hydroxyisobutyrate dehydrogenase; PFAM: 6-phosphogluconate dehydrogenase, NAD-binding. | PFAM: Protein of unknown function DUF395, YeeE/YedE; KEGG: dpr:Despr_3284 hypothetical protein. | 0.678 |
| AEH22682.1 | AEH22683.1 | TOPB45_0580 | TOPB45_0581 | 2-hydroxy-3-oxopropionate reductase; KEGG: tba:TERMP_01423 3-hydroxyisobutyrate dehydrogenase; PFAM: 6-phosphogluconate dehydrogenase, NAD-binding. | TIGRFAM: Diguanylate cyclase, predicted; PFAM: Diguanylate cyclase, predicted; KEGG: dak:DaAHT2_0262 response regulator receiver modulated diguanylate cyclase; SMART: Diguanylate cyclase, predicted. | 0.431 |
| AEH22682.1 | AEH22735.1 | TOPB45_0580 | TOPB45_0633 | 2-hydroxy-3-oxopropionate reductase; KEGG: tba:TERMP_01423 3-hydroxyisobutyrate dehydrogenase; PFAM: 6-phosphogluconate dehydrogenase, NAD-binding. | KEGG: tye:THEYE_A1654 acetyl-CoA synthetase; TIGRFAM: Acetyl coenzyme A synthetase (ADP forming), alpha domain; PFAM: CoA-binding; ATP-grasp fold, succinyl-CoA synthetase-type. | 0.811 |
| AEH22682.1 | AEH22738.1 | TOPB45_0580 | TOPB45_0636 | 2-hydroxy-3-oxopropionate reductase; KEGG: tba:TERMP_01423 3-hydroxyisobutyrate dehydrogenase; PFAM: 6-phosphogluconate dehydrogenase, NAD-binding. | Acetate--CoA ligase; KEGG: reh:H16_A1616 acetyl-coenzyme A synthetase; PFAM: AMP-dependent synthetase/ligase. | 0.852 |
| AEH22682.1 | AEH23676.1 | TOPB45_0580 | TOPB45_1598 | 2-hydroxy-3-oxopropionate reductase; KEGG: tba:TERMP_01423 3-hydroxyisobutyrate dehydrogenase; PFAM: 6-phosphogluconate dehydrogenase, NAD-binding. | TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate; KEGG: dbr:Deba_3204 pyruvate/ketoisovalerate oxidoreductase, subunit gamma; PFAM: Pyruvate/ketoisovalerate oxidoreductase. | 0.800 |
| AEH22682.1 | AEH23677.1 | TOPB45_0580 | TOPB45_1599 | 2-hydroxy-3-oxopropionate reductase; KEGG: tba:TERMP_01423 3-hydroxyisobutyrate dehydrogenase; PFAM: 6-phosphogluconate dehydrogenase, NAD-binding. | KEGG: sfu:Sfum_2793 pyruvate ferredoxin/flavodoxin oxidoreductase subunit delta; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate; PFAM: 4Fe-4S ferredoxin, iron-sulphur binding, subgroup. | 0.800 |
| AEH22682.1 | AEH23678.1 | TOPB45_0580 | TOPB45_1600 | 2-hydroxy-3-oxopropionate reductase; KEGG: tba:TERMP_01423 3-hydroxyisobutyrate dehydrogenase; PFAM: 6-phosphogluconate dehydrogenase, NAD-binding. | KEGG: dbr:Deba_3202 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal. | 0.800 |
| AEH22682.1 | AEH23679.1 | TOPB45_0580 | TOPB45_1601 | 2-hydroxy-3-oxopropionate reductase; KEGG: tba:TERMP_01423 3-hydroxyisobutyrate dehydrogenase; PFAM: 6-phosphogluconate dehydrogenase, NAD-binding. | Pyruvate synthase; KEGG: sfu:Sfum_2795 thiamine pyrophosphate binding domain-containing protein; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. | 0.800 |
| AEH22682.1 | hisG | TOPB45_0580 | TOPB45_0584 | 2-hydroxy-3-oxopropionate reductase; KEGG: tba:TERMP_01423 3-hydroxyisobutyrate dehydrogenase; PFAM: 6-phosphogluconate dehydrogenase, NAD-binding. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.446 |
| AEH22683.1 | AEH22682.1 | TOPB45_0581 | TOPB45_0580 | TIGRFAM: Diguanylate cyclase, predicted; PFAM: Diguanylate cyclase, predicted; KEGG: dak:DaAHT2_0262 response regulator receiver modulated diguanylate cyclase; SMART: Diguanylate cyclase, predicted. | 2-hydroxy-3-oxopropionate reductase; KEGG: tba:TERMP_01423 3-hydroxyisobutyrate dehydrogenase; PFAM: 6-phosphogluconate dehydrogenase, NAD-binding. | 0.431 |
| AEH22683.1 | hisG | TOPB45_0581 | TOPB45_0584 | TIGRFAM: Diguanylate cyclase, predicted; PFAM: Diguanylate cyclase, predicted; KEGG: dak:DaAHT2_0262 response regulator receiver modulated diguanylate cyclase; SMART: Diguanylate cyclase, predicted. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.777 |
| AEH22735.1 | AEH22682.1 | TOPB45_0633 | TOPB45_0580 | KEGG: tye:THEYE_A1654 acetyl-CoA synthetase; TIGRFAM: Acetyl coenzyme A synthetase (ADP forming), alpha domain; PFAM: CoA-binding; ATP-grasp fold, succinyl-CoA synthetase-type. | 2-hydroxy-3-oxopropionate reductase; KEGG: tba:TERMP_01423 3-hydroxyisobutyrate dehydrogenase; PFAM: 6-phosphogluconate dehydrogenase, NAD-binding. | 0.811 |
| AEH22735.1 | AEH22738.1 | TOPB45_0633 | TOPB45_0636 | KEGG: tye:THEYE_A1654 acetyl-CoA synthetase; TIGRFAM: Acetyl coenzyme A synthetase (ADP forming), alpha domain; PFAM: CoA-binding; ATP-grasp fold, succinyl-CoA synthetase-type. | Acetate--CoA ligase; KEGG: reh:H16_A1616 acetyl-coenzyme A synthetase; PFAM: AMP-dependent synthetase/ligase. | 0.950 |
| AEH22735.1 | AEH23676.1 | TOPB45_0633 | TOPB45_1598 | KEGG: tye:THEYE_A1654 acetyl-CoA synthetase; TIGRFAM: Acetyl coenzyme A synthetase (ADP forming), alpha domain; PFAM: CoA-binding; ATP-grasp fold, succinyl-CoA synthetase-type. | TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate; KEGG: dbr:Deba_3204 pyruvate/ketoisovalerate oxidoreductase, subunit gamma; PFAM: Pyruvate/ketoisovalerate oxidoreductase. | 0.903 |
| AEH22735.1 | AEH23677.1 | TOPB45_0633 | TOPB45_1599 | KEGG: tye:THEYE_A1654 acetyl-CoA synthetase; TIGRFAM: Acetyl coenzyme A synthetase (ADP forming), alpha domain; PFAM: CoA-binding; ATP-grasp fold, succinyl-CoA synthetase-type. | KEGG: sfu:Sfum_2793 pyruvate ferredoxin/flavodoxin oxidoreductase subunit delta; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate; PFAM: 4Fe-4S ferredoxin, iron-sulphur binding, subgroup. | 0.903 |