Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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AEH22803.1Exodeoxyribonuclease III; TIGRFAM: AP endonuclease, family 1; Exodeoxyribonuclease III xth; KEGG: hth:HTH_0512 exodeoxyribonuclease III; PFAM: Endonuclease/exonuclease/phosphatase. (267 aa)    
Predicted Functional Partners:
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
 0.993
AEH23563.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.914
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.885
birA
biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
    0.834
AEH23575.1
PHP domain protein; KEGG: adg:Adeg_1792 DNA-directed DNA polymerase; PFAM: PHP, C-terminal; Nucleotidyltransferase; SMART: DNA-directed DNA polymerase, family X; Helix-hairpin-helix DNA-binding motif, class 1; Polymerase/histidinol phosphatase, N-terminal.
   
 0.816
AEH22957.1
PFAM: ATP dependent DNA ligase, central; KEGG: tbo:Thebr_0487 DNA polymerase LigD, ligase domain-containing protein.
  
 
 0.796
AEH22802.1
KEGG: dak:DaAHT2_2010 hypothetical protein.
       0.768
AEH23252.1
TIGRFAM: Histidinol-phosphate phosphatase; HAD-superfamily hydrolase, subfamily IIIA; KEGG: dpr:Despr_1621 histidinol-phosphate phosphatase family protein; PFAM: Haloacid dehalogenase-like hydrolase.
   
 
 0.760
AEH23211.1
TIGRFAM: Pseudouridine synthase, RsuA and RluB/E/F; PFAM: RNA-binding S4; Pseudouridine synthase, RsuA and RluB/C/D/E/F; KEGG: dte:Dester_0847 pseudouridine synthase Rsu; SMART: RNA-binding S4; Belongs to the pseudouridine synthase RsuA family.
  
    0.756
AEH23233.1
TIGRFAM: Pseudouridine synthase, RsuA and RluB/E/F; PFAM: RNA-binding S4; Pseudouridine synthase, RsuA and RluB/C/D/E/F; KEGG: dth:DICTH_1356 ribosomal large subunit pseudouridine synthase B; SMART: RNA-binding S4; Belongs to the pseudouridine synthase RsuA family.
  
    0.756
Your Current Organism:
Thermodesulfobacterium geofontis
NCBI taxonomy Id: 795359
Other names: T. geofontis OPF15, Thermodesulfobacterium geofontis OPF15, Thermodesulfobacterium sp. OPF15
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