Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEH22957.1PFAM: ATP dependent DNA ligase, central; KEGG: tbo:Thebr_0487 DNA polymerase LigD, ligase domain-containing protein. (191 aa)    
Predicted Functional Partners:
AEH23563.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.959
AEH23575.1
PHP domain protein; KEGG: adg:Adeg_1792 DNA-directed DNA polymerase; PFAM: PHP, C-terminal; Nucleotidyltransferase; SMART: DNA-directed DNA polymerase, family X; Helix-hairpin-helix DNA-binding motif, class 1; Polymerase/histidinol phosphatase, N-terminal.
  
 0.958
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.931
AEH22803.1
Exodeoxyribonuclease III; TIGRFAM: AP endonuclease, family 1; Exodeoxyribonuclease III xth; KEGG: hth:HTH_0512 exodeoxyribonuclease III; PFAM: Endonuclease/exonuclease/phosphatase.
  
 
 0.796
AEH22956.1
KEGG: sto:ST1739 hypothetical protein.
       0.773
AEH22958.1
KEGG: tye:THEYE_A0630 hypothetical protein; TIGRFAM: Phenylacetic acid degradation-related protein; PFAM: Thioesterase superfamily.
       0.773
mtgA
Monofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family.
       0.709
AEH23252.1
TIGRFAM: Histidinol-phosphate phosphatase; HAD-superfamily hydrolase, subfamily IIIA; KEGG: dpr:Despr_1621 histidinol-phosphate phosphatase family protein; PFAM: Haloacid dehalogenase-like hydrolase.
   
 0.657
AEH22959.1
TIGRFAM: HDIG; PFAM: Metal-dependent hydrolase HDOD; KEGG: gsu:GSU2063 HD domain-containing protein; SMART: Metal-dependent phosphohydrolase, HD region.
       0.634
AEH22962.1
PFAM: Metallophosphoesterase; KEGG: abi:Aboo_1037 metallophosphoesterase.
  
 0.568
Your Current Organism:
Thermodesulfobacterium geofontis
NCBI taxonomy Id: 795359
Other names: T. geofontis OPF15, Thermodesulfobacterium geofontis OPF15, Thermodesulfobacterium sp. OPF15
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