Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
thi4Thiazole biosynthetic enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (254 aa)    
Predicted Functional Partners:
AEH22697.1
KEGG: aae:aq_1960 HMP-P kinase; PFAM: Phosphomethylpyrimidine kinase type-1.
 
  
 0.697
AEH23013.1
PFAM: Type II secretion system protein E; General secretory system II, protein E, N-terminal; KEGG: pmx:PERMA_0977 type IV pilus assembly protein TapB.
       0.530
AEH23014.1
PFAM: Type II secretion system F domain; KEGG: pmx:PERMA_0978 putative type II secretion system protein.
       0.530
AEH23015.1
Hypothetical protein.
       0.530
AEH23016.1
SMART: ATPase, AAA+ type, core; KEGG: pmx:PERMA_0968 peptidoglycan-binding domain 1 protein.
       0.502
AEH23017.1
Hypothetical protein.
       0.502
AEH23018.1
Hypothetical protein.
       0.502
AEH23019.1
Hypothetical protein.
       0.489
thiC
Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.430
Your Current Organism:
Thermodesulfobacterium geofontis
NCBI taxonomy Id: 795359
Other names: T. geofontis OPF15, Thermodesulfobacterium geofontis OPF15, Thermodesulfobacterium sp. OPF15
Server load: low (16%) [HD]