Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEH23073.1TIGRFAM: Sirohaem synthase, N-terminal; KEGG: adg:Adeg_1261 siroheme synthase. (231 aa)    
Predicted Functional Partners:
AEH23535.1
TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; KEGG: dsa:Desal_0251 uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole methylase; Tetrapyrrole biosynthesis, uroporphyrinogen III synthase.
 
 0.999
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.858
AEH22830.1
PFAM: Tetrapyrrole methylase; KEGG: ppd:Ppro_1250 uroporphyrin-III C/tetrapyrrole methyltransferase.
 
  
 0.844
AEH23072.1
Y414 protein; KEGG: aae:aq_1106 hypothetical protein; TIGRFAM: Y414; PFAM: ATP dependent DNA ligase, central.
       0.779
hemL
Glutamate-1-semialdehyde 2,1-aminomutase; PFAM: Aminotransferase class-III; TIGRFAM: Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase; HAMAP: Glutamate-1-semialdehyde 2,1-aminomutase; KEGG: aar:Acear_0548 glutamate-1-semialdehyde 2,1-aminomutase.
    
 0.709
rtcA
RNA 3'-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
       0.609
AEH23071.1
Hypothetical protein; KEGG: pfo:Pfl01_2836 glycosyl transferase family protein.
       0.608
AEH23069.1
PFAM: Creatininase; KEGG: sfu:Sfum_0661 creatininase.
       0.606
cysS
TIGRFAM: Cysteine synthase K/M; Cysteinyl-tRNA synthetase, class Ia; KEGG: dpr:Despr_3183 cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; Cysteinyl-tRNA synthetase, class Ia, N-terminal; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
  
 0.517
AEH23292.1
KEGG: tye:THEYE_A0001 cobyrinic acid a,c-diamide synthase; TIGRFAM: Cobyrinic acid a,c-diamide synthase CbiA; PFAM: CobB/CobQ-like glutamine amidotransferase; Cobyrinic acid a,c-diamide synthase.
 
  
 0.484
Your Current Organism:
Thermodesulfobacterium geofontis
NCBI taxonomy Id: 795359
Other names: T. geofontis OPF15, Thermodesulfobacterium geofontis OPF15, Thermodesulfobacterium sp. OPF15
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