Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEH23081.1KEGG: tye:THEYE_A1986 homoserine dehydrogenase (HDH): ThrA, MetL; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT. (431 aa)    
Predicted Functional Partners:
asd
Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.
  
 0.975
AEH23634.1
TIGRFAM: Threonine synthase; KEGG: gme:Gmet_1631 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit.
 
 
 0.964
AEH22826.1
Aspartate kinase; KEGG: tye:THEYE_A1522 asparate kinase, monofunctional class; TIGRFAM: Aspartate kinase region; Aspartate kinase, monofunctional class; PFAM: Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Belongs to the aspartokinase family.
 
 0.946
dapA
Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
 
 
 0.942
AEH22161.1
PFAM: Protein of unknown function DUF39; KEGG: sfu:Sfum_1059 hypothetical protein.
     
  0.900
AEH23592.1
NIL domain-containing protein; PFAM: NIL domain; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; KEGG: pth:PTH_1473 ferredoxin.
     
  0.900
AEH22605.1
TIGRFAM: Branched-chain amino acid aminotransferase II; KEGG: bld:BLi04084 branched-chain amino acid aminotransferase; PFAM: Aminotransferase, class IV; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.875
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
   
 
  0.811
rplS
50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
  
  
 0.771
AEH23078.1
UPF0102 protein yraN; KEGG: dtu:Dtur_1530 hypothetical protein; HAMAP: Uncharacterised protein family UPF0102; PFAM: Uncharacterised protein family UPF0102; Belongs to the UPF0102 family.
       0.768
Your Current Organism:
Thermodesulfobacterium geofontis
NCBI taxonomy Id: 795359
Other names: T. geofontis OPF15, Thermodesulfobacterium geofontis OPF15, Thermodesulfobacterium sp. OPF15
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