Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEH23217.1PFAM: Cytochrome c, class III; KEGG: tye:THEYE_A1056 cytochrome c3 chain A. (129 aa)    
Predicted Functional Partners:
AEH23216.1
KEGG: tye:THEYE_A1057 hydrogen sulfide production: membrane anchoring protein.
 
     0.830
dnaK
Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
   
 0.783
AEH23215.1
Hypothetical protein; KEGG: tye:THEYE_A1058 cytochrome c family protein, putative.
 
     0.769
grpE
Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
   
 
 0.651
AEH23321.1
KEGG: tye:THEYE_A1505 hypothetical protein.
  
     0.570
AEH23572.1
KEGG: tye:THEYE_A1285 hypothetical protein.
 
    0.566
groL
60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
   
 0.560
AEH23320.1
PFAM: Uncharacterised protein family, carbohydrate kinase-related; KEGG: tye:THEYE_A1504 hypothetical protein.
  
     0.541
AEH23573.1
KEGG: tye:THEYE_A1286 hypothetical protein.
  
    0.507
AEH22952.1
PFAM: Protein of unknown function, CGGC domain; KEGG: tye:THEYE_A1863 hypothetical protein.
  
     0.504
Your Current Organism:
Thermodesulfobacterium geofontis
NCBI taxonomy Id: 795359
Other names: T. geofontis OPF15, Thermodesulfobacterium geofontis OPF15, Thermodesulfobacterium sp. OPF15
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