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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)    
Predicted Functional Partners:
AEH22307.1
KEGG: tam:Theam_1017 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Fumarate lyase; Adenylosuccinate lyase, C-terminal.
 
 0.996
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.989
purL
Phosphoribosylformylglycinamidine synthase 2; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...]
  
  
 0.971
AEH22143.1
Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dak:DaAHT2_1420 IMP cyclohydrolase; SMART: AICARFT/IMPCHase bienzyme, formylation region.
  
 0.961
AEH23583.1
Phosphoribosylaminoimidazolecarboxamide formyltransferase; KEGG: dte:Dester_0983 bifunctional purine biosynthesis protein PurH; PFAM: MGS-like; AICARFT/IMPCHase bienzyme, formylation region.
  
 0.961
AEH23565.1
TIGRFAM: Hypoxanthine phosphoribosyl transferase; KEGG: cdl:CDR20291_2579 putative phosphoribosyltransferase; PFAM: Phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.939
pyrB
PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; TIGRFAM: Aspartate carbamoyltransferase, eukaryotic; HAMAP: Aspartate carbamoyltransferase; KEGG: dth:DICTH_1465 aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
 
 0.935
AEH22611.1
KEGG: pvi:Cvib_0642 hypothetical protein.
   
 
 0.928
argG
PFAM: Argininosuccinate synthase; TIGRFAM: Argininosuccinate synthase; HAMAP: Argininosuccinate synthase; KEGG: tsc:TSC_c02740 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
   
 
 0.920
AEH23690.1
L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.
     
 0.912
Your Current Organism:
Thermodesulfobacterium geofontis
NCBI taxonomy Id: 795359
Other names: T. geofontis OPF15, Thermodesulfobacterium geofontis OPF15, Thermodesulfobacterium sp. OPF15
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