Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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AEH23575.1PHP domain protein; KEGG: adg:Adeg_1792 DNA-directed DNA polymerase; PFAM: PHP, C-terminal; Nucleotidyltransferase; SMART: DNA-directed DNA polymerase, family X; Helix-hairpin-helix DNA-binding motif, class 1; Polymerase/histidinol phosphatase, N-terminal. (606 aa)    
Predicted Functional Partners:
AEH22957.1
PFAM: ATP dependent DNA ligase, central; KEGG: tbo:Thebr_0487 DNA polymerase LigD, ligase domain-containing protein.
  
 0.958
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 0.911
AEH23574.1
PFAM: ABC transporter-like; KEGG: tye:THEYE_A1038 excinuclease ABC, A subunit.
 
     0.838
AEH23252.1
TIGRFAM: Histidinol-phosphate phosphatase; HAD-superfamily hydrolase, subfamily IIIA; KEGG: dpr:Despr_1621 histidinol-phosphate phosphatase family protein; PFAM: Haloacid dehalogenase-like hydrolase.
    
 0.826
AEH22803.1
Exodeoxyribonuclease III; TIGRFAM: AP endonuclease, family 1; Exodeoxyribonuclease III xth; KEGG: hth:HTH_0512 exodeoxyribonuclease III; PFAM: Endonuclease/exonuclease/phosphatase.
   
 0.816
AEH23563.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
    
 0.687
mutS2
MutS2 protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
  
  
 0.628
AEH23576.1
Serine-type D-Ala-D-Ala carboxypeptidase; KEGG: tye:THEYE_A1325 D-alanyl-D-alanine carboxypeptidase; PFAM: Peptidase S11, D-alanyl-D-alanine carboxypeptidase A.
       0.619
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
     
 0.526
AEH23577.1
TIGRFAM: Nucleotide sugar dehydrogenase; KEGG: cni:Calni_2007 nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase, N-terminal; UDP-glucose/GDP-mannose dehydrogenase, dimerisation; UDP-glucose/GDP-mannose dehydrogenase, C-terminal.
       0.522
Your Current Organism:
Thermodesulfobacterium geofontis
NCBI taxonomy Id: 795359
Other names: T. geofontis OPF15, Thermodesulfobacterium geofontis OPF15, Thermodesulfobacterium sp. OPF15
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