Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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AEH23610.14-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; TIGRFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; HAMAP: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; KEGG: tye:THEYE_A1148 4-hydroxythreonine-4-phosphate dehydrogenase; Belongs to the PdxA family. (315 aa)    
Predicted Functional Partners:
pdxJ
Metalloprotease ybeY; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. Belongs to the endoribonuclease YbeY family.
 
 
 0.903
dnaK
Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
       0.778
grpE
Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
       0.697
AEH23608.1
PFAM: Pseudouridine synthase, RsuA and RluB/C/D/E/F; KEGG: dth:DICTH_0081 ribosomal large subunit pseudouridine synthase C.
 
     0.676
AEH23609.1
KEGG: sfu:Sfum_3774 membrane protein-like.
       0.633
argS
TIGRFAM: Arginyl-tRNA synthetase, class Ic; HAMAP: Arginyl-tRNA synthetase, class Ic; KEGG: dte:Dester_1092 arginyl-tRNA synthetase.
       0.582
AEH23607.1
Hypothetical protein.
       0.582
AEH23604.1
PFAM: GCN5-related N-acetyltransferase; KEGG: tye:THEYE_A1043 bifunctional protein argHA; Belongs to the acetyltransferase family.
       0.565
AEH23605.1
Sporulation domain-containing protein; PFAM: Sporulation/cell division region, bacteria; KEGG: xal:XALc_0565 hypothetical protein.
       0.555
ribBA
GTP cyclohydrolase-2; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
  
  
 0.545
Your Current Organism:
Thermodesulfobacterium geofontis
NCBI taxonomy Id: 795359
Other names: T. geofontis OPF15, Thermodesulfobacterium geofontis OPF15, Thermodesulfobacterium sp. OPF15
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