| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEH22806.1 | AEH23136.1 | TOPB45_0704 | TOPB45_1042 | TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic; Intein splicing site; PFAM: ATP-cone; KEGG: cow:Calow_0403 anaerobic ribonucleoside-triphosphate reductase; SMART: Hedgehog/intein hint, N-terminal. | TIGRFAM: Pyruvate kinase; KEGG: pmx:PERMA_0022 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; Belongs to the pyruvate kinase family. | 0.900 |
| AEH22806.1 | AEH23494.1 | TOPB45_0704 | TOPB45_1413 | TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic; Intein splicing site; PFAM: ATP-cone; KEGG: cow:Calow_0403 anaerobic ribonucleoside-triphosphate reductase; SMART: Hedgehog/intein hint, N-terminal. | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.900 |
| AEH22806.1 | AEH23685.1 | TOPB45_0704 | TOPB45_1607 | TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic; Intein splicing site; PFAM: ATP-cone; KEGG: cow:Calow_0403 anaerobic ribonucleoside-triphosphate reductase; SMART: Hedgehog/intein hint, N-terminal. | KEGG: cac:CA_C1303 hypothetical protein; TIGRFAM: NGG1p interacting factor 3, NIF3; PFAM: NGG1p interacting factor 3, NIF3. | 0.800 |
| AEH22806.1 | folE2 | TOPB45_0704 | TOPB45_0461 | TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic; Intein splicing site; PFAM: ATP-cone; KEGG: cow:Calow_0403 anaerobic ribonucleoside-triphosphate reductase; SMART: Hedgehog/intein hint, N-terminal. | Protein of unknown function DUF198; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.800 |
| AEH22806.1 | moaA | TOPB45_0704 | TOPB45_1188 | TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic; Intein splicing site; PFAM: ATP-cone; KEGG: cow:Calow_0403 anaerobic ribonucleoside-triphosphate reductase; SMART: Hedgehog/intein hint, N-terminal. | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 0.805 |
| AEH22806.1 | ndk | TOPB45_0704 | TOPB45_1011 | TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic; Intein splicing site; PFAM: ATP-cone; KEGG: cow:Calow_0403 anaerobic ribonucleoside-triphosphate reductase; SMART: Hedgehog/intein hint, N-terminal. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.910 |
| AEH22806.1 | ribBA | TOPB45_0704 | TOPB45_0960 | TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic; Intein splicing site; PFAM: ATP-cone; KEGG: cow:Calow_0403 anaerobic ribonucleoside-triphosphate reductase; SMART: Hedgehog/intein hint, N-terminal. | GTP cyclohydrolase-2; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.800 |
| AEH23136.1 | AEH22806.1 | TOPB45_1042 | TOPB45_0704 | TIGRFAM: Pyruvate kinase; KEGG: pmx:PERMA_0022 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; Belongs to the pyruvate kinase family. | TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic; Intein splicing site; PFAM: ATP-cone; KEGG: cow:Calow_0403 anaerobic ribonucleoside-triphosphate reductase; SMART: Hedgehog/intein hint, N-terminal. | 0.900 |
| AEH23136.1 | AEH23494.1 | TOPB45_1042 | TOPB45_1413 | TIGRFAM: Pyruvate kinase; KEGG: pmx:PERMA_0022 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; Belongs to the pyruvate kinase family. | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.903 |
| AEH23136.1 | AEH23685.1 | TOPB45_1042 | TOPB45_1607 | TIGRFAM: Pyruvate kinase; KEGG: pmx:PERMA_0022 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; Belongs to the pyruvate kinase family. | KEGG: cac:CA_C1303 hypothetical protein; TIGRFAM: NGG1p interacting factor 3, NIF3; PFAM: NGG1p interacting factor 3, NIF3. | 0.844 |
| AEH23136.1 | folE2 | TOPB45_1042 | TOPB45_0461 | TIGRFAM: Pyruvate kinase; KEGG: pmx:PERMA_0022 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; Belongs to the pyruvate kinase family. | Protein of unknown function DUF198; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.810 |
| AEH23136.1 | moaA | TOPB45_1042 | TOPB45_1188 | TIGRFAM: Pyruvate kinase; KEGG: pmx:PERMA_0022 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; Belongs to the pyruvate kinase family. | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 0.800 |
| AEH23136.1 | ndk | TOPB45_1042 | TOPB45_1011 | TIGRFAM: Pyruvate kinase; KEGG: pmx:PERMA_0022 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; Belongs to the pyruvate kinase family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.907 |
| AEH23136.1 | ribBA | TOPB45_1042 | TOPB45_0960 | TIGRFAM: Pyruvate kinase; KEGG: pmx:PERMA_0022 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; Belongs to the pyruvate kinase family. | GTP cyclohydrolase-2; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.800 |
| AEH23427.1 | AEH23685.1 | TOPB45_1346 | TOPB45_1607 | Queuosine biosynthesis protein QueD; KEGG: ddf:DEFDS_1007 6-pyruvoyl-tetrahydropterin synthase; TIGRFAM: queuosine biosynthesis protein QueD; PFAM: 6-pyruvoyl tetrahydropterin synthase-related. | KEGG: cac:CA_C1303 hypothetical protein; TIGRFAM: NGG1p interacting factor 3, NIF3; PFAM: NGG1p interacting factor 3, NIF3. | 0.901 |
| AEH23427.1 | folE2 | TOPB45_1346 | TOPB45_0461 | Queuosine biosynthesis protein QueD; KEGG: ddf:DEFDS_1007 6-pyruvoyl-tetrahydropterin synthase; TIGRFAM: queuosine biosynthesis protein QueD; PFAM: 6-pyruvoyl tetrahydropterin synthase-related. | Protein of unknown function DUF198; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.922 |
| AEH23494.1 | AEH22806.1 | TOPB45_1413 | TOPB45_0704 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic; Intein splicing site; PFAM: ATP-cone; KEGG: cow:Calow_0403 anaerobic ribonucleoside-triphosphate reductase; SMART: Hedgehog/intein hint, N-terminal. | 0.900 |
| AEH23494.1 | AEH23136.1 | TOPB45_1413 | TOPB45_1042 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | TIGRFAM: Pyruvate kinase; KEGG: pmx:PERMA_0022 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; Belongs to the pyruvate kinase family. | 0.903 |
| AEH23494.1 | AEH23685.1 | TOPB45_1413 | TOPB45_1607 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | KEGG: cac:CA_C1303 hypothetical protein; TIGRFAM: NGG1p interacting factor 3, NIF3; PFAM: NGG1p interacting factor 3, NIF3. | 0.802 |
| AEH23494.1 | folE2 | TOPB45_1413 | TOPB45_0461 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Protein of unknown function DUF198; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.800 |