Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mcm6lDNA helicase; Belongs to the MCM family. (824 aa)    
Predicted Functional Partners:
mcm4
DNA helicase; Belongs to the MCM family.
   
0.999
mcm5
DNA helicase; Belongs to the MCM family.
   
0.998
mcm7
DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]
   
0.998
mcm2
DNA helicase; Belongs to the MCM family.
   
0.998
mcm3
DNA helicase; Belongs to the MCM family.
   
0.996
mcm3l
DNA helicase; Belongs to the MCM family.
   
0.996
mcm6
DNA helicase; Belongs to the MCM family.
  
 
 
0.994
cdt1
Chromatin licensing and DNA replication factor 1.
   
 0.992
mcmbp
Mini-chromosome maintenance complex-binding protein; Associated component of the mcm complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the mcm complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the mcm complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the mcm complex. Required for sister chromatid cohesion (By similarity).
   
 0.990
cdc45
CDC45 cell division cycle 45 homolog (S. cerevisiae).
   
 0.988
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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