Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mctp2aMultiple C2 domains, transmembrane 2a. (927 aa)    
Predicted Functional Partners:
acin1a
Apoptotic chromatin condensation inducer 1a.
      
 0.819
rereb
Arginine-glutamic acid dipeptide (RE) repeats b.
      
 0.799
tead1b
TEA domain family member 1b.
      
 0.783
adra1ba
Adrenoceptor alpha 1Ba.
      
 0.780
inppl1b
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of [...]
      
 0.690
rev1
DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.
      
 0.688
furina
Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family.
      
 0.628
furinb
Furin (paired basic amino acid cleaving enzyme) b; Belongs to the peptidase S8 family.
      
 0.611
rerea
Arginine-glutamic acid dipeptide (RE) repeats a.
      
 0.594
itk
Tyrosine-protein kinase.
      
 0.581
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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