STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nr4a1Nuclear receptor subfamily 4, group A, member 1. (574 aa)    
Predicted Functional Partners:
npas4a
Neuronal PAS domain-containing protein 4A; Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus. Plays a key role in the structural and functional plasticity of neurons. Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late- response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal act [...]
   
  
 0.777
akt2
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
  0.755
akt3b
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
  0.755
fosb
FBJ murine osteosarcoma viral oncogene homolog B.
   
 
 0.637
btg2
Anti-proliferative cofactor.
   
  
 0.626
fosab
V-fos FBJ murine osteosarcoma viral oncogene homolog Ab.
   
 
 0.602
atf3
Activating transcription factor 3.
   
 
 0.571
nr1d2a
Nuclear receptor subfamily 1, group D, member 2a.
   
0.569
dusp1
Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.
   
  
 0.569
ncor2
Nuclear receptor corepressor 2.
    
 0.566
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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