STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ptchd4Patched domain-containing protein 1. (897 aa)    
Predicted Functional Partners:
syngap1b
Synaptic Ras GTPase-activating protein 1b.
   
  
 0.812
dpp6b
Dipeptidyl-peptidase 6b; Belongs to the peptidase S9B family.
   
  
 0.679
gpr85
Probable G protein-coupled receptor 85; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.646
vps26b
Vacuolar protein sorting-associated protein 26B; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity).
    
 
 0.602
plagl2
Pleiomorphic adenoma gene-like 2.
      
 0.585
cntn4
Contactin 4.
   
  
 0.562
shank2b
SH3 and multiple ankyrin repeat domains 2b.
   
  
 0.535
zic1
ZIC family member 1 (Odd-paired homolog, Drosophila).
      
 0.529
dlg3
Discs, large homolog 3 (Drosophila); Belongs to the MAGUK family.
    
 
 0.484
afap1l2
Actin filament-associated protein 1-like 2.
   
  
 0.483
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (18%) [ZH]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.