STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tlk2Serine/threonine-protein kinase tousled-like 2; Negative regulator of amino acid starvation-induced autophagy; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (697 aa)    
Predicted Functional Partners:
smpd2b
Sphingomyelin phosphodiesterase 2b.
      
 0.844
asf1ba
Histone chaperone asf1b-A; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
    
 
 0.827
psmf1
Proteasome inhibitor subunit 1.
      
 0.751
asf1bb
Histone chaperone asf1b-B; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
   
 
 0.703
tpst2
Protein-tyrosine sulfotransferase; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family.
      
 0.583
usp39
Ubiquitin-specific peptidase 39.
   
  
 0.530
psmc6
Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family.
      
 0.526
tubg1
Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.
   
  
 0.453
adnpb
Activity-dependent neuroprotector homeobox b.
   
  
 0.429
cabin1
Calcineurin-binding protein 1.
    
 
 0.424
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.