STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ube2v2Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The ube2v2/ube2n heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity); Belongs to the ubiquitin-c [...] (145 aa)    
Predicted Functional Partners:
ube2na
Ubiquitin-conjugating enzyme E2Na; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.998
ube2nb
Ubiquitin-conjugating enzyme E2N-like; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.991
hltf
Helicase-like transcription factor.
   
 0.971
rps27a
Ribosomal protein S27a.
   
 0.962
ubc
Ubiquitin C.
   
 0.953
UBB
Si:ch211-202a12.4.
   
 0.945
ubb
Ubiquitin B.
   
 0.923
rev3l
REV3-like, DNA directed polymerase zeta catalytic subunit.
   
 
 0.913
rnf8
E3 ubiquitin-protein ligase rnf8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated mdc1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of tp53 [...]
   
 0.907
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
   
 
 0.900
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.