STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
arih1E3 ubiquitin-protein ligase arih1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin- conjugating enzyme E2 ube2l3. Acts as an atypical E3 ubiquitin- protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase com [...] (527 aa)    
Predicted Functional Partners:
ube2na
Ubiquitin-conjugating enzyme E2Na; Belongs to the ubiquitin-conjugating enzyme family
   
 0.945
ube2e2
Ubiquitin-conjugating enzyme E2E 2; Belongs to the ubiquitin-conjugating enzyme family
   
 0.941
ube2l3b
Ubiquitin-conjugating enzyme e2 l3b; Ubiquitin-conjugating enzyme E2L 3b; Belongs to the ubiquitin-conjugating enzyme family
   
 0.938
ube2nb
Ubiquitin-conjugating enzyme e2n-like; Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family
   
 0.935
ppm1bb
Protein phosphatase 1A, magnesium dependent, alpha isoform; Protein phosphatase, Mg2+/Mn2+ dependent, 1Bb
   
 0.928
irf3
Interferon regulatory factor 3
     
 0.923
jak1
Tyrosine-protein kinase jak1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures
   
 0.911
plcg1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; Phospholipase C, gamma 1
    
 0.908
ifit9
Interferon-induced protein with tetratricopeptide repeats 9; Si:dkey-26g8.12
    
 0.907
ifit11
Interferon-induced protein with tetratricopeptide repeats 11; Si:dkey-26g8.10
    
 0.907
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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