STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sec63SEC63 homolog, protein translocation regulator. (751 aa)    
Predicted Functional Partners:
sec62
SEC62 homolog, preprotein translocation factor.
   
 0.999
sec61a1l
Protein transport protein Sec61 subunit alpha-like 2; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity).
   
 
 0.999
sec61a1
Protein transport protein Sec61 subunit alpha-like 1; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adapter proteins (By similarity). Plays a role in the pronephric kidney tubule development.
   
 
 0.998
sec61b
Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.
   
 
 0.998
sec61g
SEC61 translocon gamma subunit.
    
 
 0.997
prkcsh
Protein kinase C substrate 80K-H.
   
  
 0.994
ankrd45
Ankyrin repeat domain 45.
  
 
 0.958
hspa5
Immunoglobulin binding protein; Belongs to the heat shock protein 70 family.
  
 
 0.958
spcs2
Probable signal peptidase complex subunit 2; Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
   
 
 0.872
spcs1
Signal peptidase complex subunit 1 homolog (S. cerevisiae).
   
 
 0.867
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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