STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
atf7aCyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (497 aa)    
Predicted Functional Partners:
plcd1a
Phosphoinositide phospholipase C.
      
 0.856
camk2d1
Calcium/calmodulin-dependent protein kinase type II delta 1 chain; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system.
      
 0.834
cacna2d4b
Calcium channel, voltage-dependent, alpha 2/delta subunit 4b.
      
 0.807
atf4b
Activating transcription factor 4b.
    
 
 0.755
cacng8b
Calcium channel, voltage-dependent, gamma subunit 8b.
      
 0.745
cacnb2a
Calcium channel, voltage-dependent, beta 2a.
   
  
 0.745
cacnb2b
Voltage-dependent calcium channel beta 2a subunit.
      
 0.744
cacng1a
Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
      
 0.692
atf7ip
Activating transcription factor 7-interacting protein 1; Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing histone methyltransferase activity. May belong to a complex that represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (By similarity); Belongs to the MCAF family.
    
 
 0.684
gna14
Guanine nucleotide-binding protein (G protein), alpha 14.
      
 0.670
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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