STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fezf1Fez family zinc finger protein 1; Transcription repressor. Involved in the development of the forebrain region (By similarity); Belongs to the krueppel C2H2-type zinc-finger protein family. (429 aa)    
Predicted Functional Partners:
lhx2b
LIM homeobox 2b.
  
 
 0.698
lhx9
LIM/homeobox protein Lhx9; May be involved in gonadal development.
  
 
 0.629
otx1
Homeobox protein OTX1 B; May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain; Belongs to the paired homeobox family. Bicoid subfamily.
   
 
 0.583
sox14
Transcription factor Sox-14; Acts as a negative regulator of transcription. May function as a switch in neuronal development (By similarity).
   
 
 0.571
irx3a
Iroquois 3 homeobox protein.
   
 
 0.569
foxg1a
Forkhead box G1a.
   
 
 0.534
prok2
Prokineticin 2.
      
 0.533
lhx5
LIM/homeobox protein Lhx5; Probably involved in the patterning of the nervous system, in particular in the early specification of the diencephalon.
   
 
 0.529
gbx2
Gastrulation brain homeo box 2.
   
 
 0.508
tle3a
Transducin-like enhancer protein 3-A; Transcriptional corepressor that binds to a number of transcription factors. Enhances the transcriptional repression activity of pnx; Belongs to the WD repeat Groucho/TLE family.
    
 
 0.507
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.