STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
setbSET nuclear proto-oncogene b; Belongs to the nucleosome assembly protein (NAP) family. (275 aa)    
Predicted Functional Partners:
anp32a
Acidic leucine-rich nuclear phosphoprotein 32 family member A; Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex.
   
 0.877
xpo1b
Exportin 1 (CRM1 homolog, yeast) b.
    
  0.808
tnfsf12
Tumor necrosis factor superfamily member 12; Belongs to the tumor necrosis factor family.
     
  0.800
h2az2a
Histone H2A.V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for c [...]
   
 
 0.683
h2az2b
Histone H2A; Belongs to the histone H2A family.
   
 
 0.663
elavl1a
ELAV-like protein; Belongs to the RRM elav family.
   
  0.656
asf1bb
Histone chaperone asf1b-B; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
   
 
 0.645
asf1ba
Histone chaperone asf1b-A; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
   
 
 0.641
ptges3a
Prostaglandin E synthase 3a (cytosolic).
   
    0.620
epdl2
Ependymin-like 2.
      
 0.582
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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