| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cyp17a1 | cyp17a2 | ENSDARP00000043155 | ENSDARP00000070565 | Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Cytochrome P450, family 17, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. | 0.950 |
| cyp17a1 | cyp19a1a | ENSDARP00000043155 | ENSDARP00000111604 | Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | 0.980 |
| cyp17a1 | cyp26a1 | ENSDARP00000043155 | ENSDARP00000041727 | Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | 0.478 |
| cyp17a1 | cyp26b1 | ENSDARP00000043155 | ENSDARP00000101543 | Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development; Belongs to the cytochrome P450 family. | 0.472 |
| cyp17a1 | cyp26c1 | ENSDARP00000043155 | ENSDARP00000072275 | Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Cytochrome P450, family 26, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. | 0.425 |
| cyp17a1 | cyp3c1 | ENSDARP00000043155 | ENSDARP00000009507 | Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Cytochrome P450, family 3, subfamily c, polypeptide 1; Belongs to the cytochrome P450 family. | 0.815 |
| cyp17a1 | cyp7a1 | ENSDARP00000043155 | ENSDARP00000113850 | Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 0.961 |
| cyp17a1 | hsd17b2 | ENSDARP00000043155 | ENSDARP00000066984 | Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Hydroxysteroid (17-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.979 |
| cyp17a1 | ugt1a1 | ENSDARP00000043155 | ENSDARP00000019395 | Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.908 |
| cyp17a2 | cyp17a1 | ENSDARP00000070565 | ENSDARP00000043155 | Cytochrome P450, family 17, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. | Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | 0.950 |
| cyp17a2 | cyp19a1a | ENSDARP00000070565 | ENSDARP00000111604 | Cytochrome P450, family 17, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | 0.976 |
| cyp17a2 | cyp26a1 | ENSDARP00000070565 | ENSDARP00000041727 | Cytochrome P450, family 17, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | 0.458 |
| cyp17a2 | cyp26b1 | ENSDARP00000070565 | ENSDARP00000101543 | Cytochrome P450, family 17, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. | Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development; Belongs to the cytochrome P450 family. | 0.467 |
| cyp17a2 | cyp26c1 | ENSDARP00000070565 | ENSDARP00000072275 | Cytochrome P450, family 17, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. | Cytochrome P450, family 26, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. | 0.402 |
| cyp17a2 | cyp3c1 | ENSDARP00000070565 | ENSDARP00000009507 | Cytochrome P450, family 17, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. | Cytochrome P450, family 3, subfamily c, polypeptide 1; Belongs to the cytochrome P450 family. | 0.791 |
| cyp17a2 | cyp7a1 | ENSDARP00000070565 | ENSDARP00000113850 | Cytochrome P450, family 17, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 0.953 |
| cyp17a2 | hsd17b2 | ENSDARP00000070565 | ENSDARP00000066984 | Cytochrome P450, family 17, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. | Hydroxysteroid (17-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.968 |
| cyp17a2 | ugt1a1 | ENSDARP00000070565 | ENSDARP00000019395 | Cytochrome P450, family 17, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.891 |
| cyp19a1a | cyp17a1 | ENSDARP00000111604 | ENSDARP00000043155 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | 0.980 |
| cyp19a1a | cyp17a2 | ENSDARP00000111604 | ENSDARP00000070565 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Cytochrome P450, family 17, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. | 0.976 |
