Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
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[Homology]
Score
npr1bGuanylate cyclase. (1065 aa)    
Predicted Functional Partners:
nppa
Natriuretic peptide A.
    
 0.962
nppb
Natriuretic peptide B.
    
 0.931
pde3a
Phosphodiesterase.
    
 0.887
pde3b
Phosphodiesterase.
    
 0.878
nppc
Natriuretic peptide C.
    
 0.876
npr1a
Guanylate cyclase.
     
  0.871
pde6b
Phosphodiesterase.
    
 0.867
nudt2
Nudix (nucleoside diphosphate-linked moiety X)-type motif 2.
     
  0.856
pde6gb
Phosphodiesterase 6G, cGMP-specific, rod, gamma, paralog b.
     
 0.853
pde10a
Phosphodiesterase.
    
 0.846
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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