STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cbr4Carbonyl reductase family member 4; The heterotetramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD. The homotetramer has NADPH-dependent quinone reductase activity. Both homotetramer and the heterotetramer have broad in vitro substrate specificity and can reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o- quinones and p-quinones; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (237 aa)    
Predicted Functional Partners:
hsd17b8
FabG (Beta-ketoacyl-[acyl-carrier-protein] reductase, E. coli) like.
  
0.990
oxsm
3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
 0.982
fasn
Coiled-coil domain containing 57.
  
 0.942
mrpl16
Mitochondrial ribosomal protein L16; Belongs to the universal ribosomal protein uL16 family.
   
  
 0.869
ENSDARP00000156938
Si:ch211-212d10.1; Belongs to the peptidase S1 family.
    
 
 0.863
pcca
Propionyl-CoA carboxylase subunit alpha.
  
 0.788
mrps6
Mitochondrial ribosomal protein S6.
   
  
 0.734
F13A1
Coagulation factor XIII A chain.
   
 
 0.697
f13a1b
Coagulation factor XIII, A1 polypeptide b.
   
 
 0.674
dnph1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
   
  
 0.672
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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