| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SHC3 | erbb2 | ENSDARP00000139836 | ENSDARP00000010252 | SHC adaptor protein 3. | Receptor protein-tyrosine kinase. | 0.977 |
| SHC3 | grb2b | ENSDARP00000139836 | ENSDARP00000122829 | SHC adaptor protein 3. | Growth factor receptor-bound protein 2b. | 0.991 |
| SHC3 | pik3r1 | ENSDARP00000139836 | ENSDARP00000056212 | SHC adaptor protein 3. | Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). | 0.562 |
| SHC3 | shc1 | ENSDARP00000139836 | ENSDARP00000089171 | SHC adaptor protein 3. | SHC (Src homology 2 domain-containing)-transforming protein 1. | 0.948 |
| ctnnb1 | egf | ENSDARP00000139205 | ENSDARP00000069126 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Epidermal growth factor. | 0.839 |
| ctnnb1 | erbb2 | ENSDARP00000139205 | ENSDARP00000010252 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Receptor protein-tyrosine kinase. | 0.989 |
| ctnnb1 | fgf1a | ENSDARP00000139205 | ENSDARP00000008825 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Putative fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with i [...] | 0.549 |
| ctnnb1 | grb2b | ENSDARP00000139205 | ENSDARP00000122829 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Growth factor receptor-bound protein 2b. | 0.459 |
| ctnnb1 | nrg1 | ENSDARP00000139205 | ENSDARP00000131493 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Neuregulin 1. | 0.512 |
| ctnnb1 | pik3ca | ENSDARP00000139205 | ENSDARP00000138914 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.541 |
| ctnnb1 | pik3r1 | ENSDARP00000139205 | ENSDARP00000056212 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). | 0.586 |
| egf | ctnnb1 | ENSDARP00000069126 | ENSDARP00000139205 | Epidermal growth factor. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.839 |
| egf | erbb2 | ENSDARP00000069126 | ENSDARP00000010252 | Epidermal growth factor. | Receptor protein-tyrosine kinase. | 0.994 |
| egf | fgf1a | ENSDARP00000069126 | ENSDARP00000008825 | Epidermal growth factor. | Putative fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with i [...] | 0.802 |
| egf | grb2b | ENSDARP00000069126 | ENSDARP00000122829 | Epidermal growth factor. | Growth factor receptor-bound protein 2b. | 0.746 |
| egf | nrg1 | ENSDARP00000069126 | ENSDARP00000131493 | Epidermal growth factor. | Neuregulin 1. | 0.784 |
| egf | pik3ca | ENSDARP00000069126 | ENSDARP00000138914 | Epidermal growth factor. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.486 |
| egf | tgfa | ENSDARP00000069126 | ENSDARP00000070540 | Epidermal growth factor. | Transforming growth factor, alpha. | 0.973 |
| erbb2 | SHC3 | ENSDARP00000010252 | ENSDARP00000139836 | Receptor protein-tyrosine kinase. | SHC adaptor protein 3. | 0.977 |
| erbb2 | ctnnb1 | ENSDARP00000010252 | ENSDARP00000139205 | Receptor protein-tyrosine kinase. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.989 |
