Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
rfx1aRegulatory factor X, 1a (influences HLA class II expression). (897 aa)    
Predicted Functional Partners:
fhl3b
Four and a half LIM domains 3b.
    
 
 0.989
zbtb18
Zinc finger and BTB domain-containing protein 18; Transcriptional repressor that plays a role in various developmental processes. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes (By similarity). Belongs to the krueppel C2H2-type zinc-finger protein family. ZBTB18 subfamily.
    
 
 0.831
chek2
Checkpoint kinase 2.
    
 0.751
rorca
RAR-related orphan receptor C a.
      
 0.720
tgif1
TGFB-induced factor homeobox 1.
      
 0.683
spi1a
Spi-1 proto-oncogene a.
      
 0.683
irf5
Interferon regulatory factor 5.
    
 
 0.671
atr
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
    
 
 0.668
rfxap
Regulatory factor X-associated protein.
    
 0.658
btaf1
BTAF1 RNA polymerase II, B-TFIID transcription factor-associated.
    
   0.625
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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