Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-expression
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[Homology]
Score
hsp70.3Heat shock cognate 70-kd protein, tandem duplicate 3; Belongs to the heat shock protein 70 family. (643 aa)    
Predicted Functional Partners:
hsp90aa1.1
Heat shock protein HSP 90-alpha 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a [...]
   
 0.998
hspd1
Heat shock 60kD protein 1 (Chaperonin); Belongs to the chaperonin (HSP60) family.
  
 0.964
hsp90ab1
Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]
   
 0.960
hsp90b1
Heat shock protein 90, beta (Grp94), member 1.
   
 0.946
dnaja1
DnaJ heat shock protein family (Hsp40) member A1.
 
 0.943
hsp90aa1.2
Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.
   
 0.934
hspb1
Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family.
   
 0.928
dnajb1a
DnaJ heat shock protein family (Hsp40) member B1a.
 
 0.914
stip1
Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein).
  
 0.910
bag3
BCL2-associated athanogene 3.
   
 0.909
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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