| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| alyref | nsun2 | ENSDARP00000139993 | ENSDARP00000118997 | Aly/REF export factor. | NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | 0.950 |
| alyref | pabpc1a | ENSDARP00000139993 | ENSDARP00000021064 | Aly/REF export factor. | Polyadenylate-binding protein 1A; Binds the poly(A) tail of mRNA (By similarity). Prevents mRNA deadenylation and confers poly(A) stability (By similarity). Stimulates the translation of mRNAs to which it is bound, acting, at least in part, with dazl (By similarity). Involved in the maternal-to-zygotic transition in early embryo via interaction with ybx1: interaction recruits pabpc1a on C5-methylcytosine (m5C)-containing maternal mRNAs, preventing their degradation. Belongs to the polyadenylate-binding protein type-1 family. | 0.693 |
| alyref | ybx1 | ENSDARP00000139993 | ENSDARP00000010482 | Aly/REF export factor. | Y-box-binding protein 1; DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing and transcription regulation. Binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C). Promotes mRNA stabilization: acts by binding to m5C- containing mRNAs and recruiting pabpc1a, thereby preventing mRNA decay. Plays a role in the maternal-to-zygotic transition in early embryo by binding to m5C-containing maternal mRNAs and preventing their degradation. Also [...] | 0.920 |
| ccnd1 | sympk | ENSDARP00000140550 | ENSDARP00000077314 | G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. | Symplekin. | 0.944 |
| ccnd1 | tjp1a | ENSDARP00000140550 | ENSDARP00000156719 | G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. | Tight junction protein 1a; Belongs to the MAGUK family. | 0.411 |
| ccnd1 | tp53 | ENSDARP00000140550 | ENSDARP00000116736 | G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. | 0.949 |
| ccnd1 | ybx1 | ENSDARP00000140550 | ENSDARP00000010482 | G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. | Y-box-binding protein 1; DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing and transcription regulation. Binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C). Promotes mRNA stabilization: acts by binding to m5C- containing mRNAs and recruiting pabpc1a, thereby preventing mRNA decay. Plays a role in the maternal-to-zygotic transition in early embryo by binding to m5C-containing maternal mRNAs and preventing their degradation. Also [...] | 0.911 |
| ddx61 | pabpc1a | ENSDARP00000129311 | ENSDARP00000021064 | DEAD (Asp-Glu-Ala-Asp) box helicase 61; Belongs to the DEAD box helicase family. | Polyadenylate-binding protein 1A; Binds the poly(A) tail of mRNA (By similarity). Prevents mRNA deadenylation and confers poly(A) stability (By similarity). Stimulates the translation of mRNAs to which it is bound, acting, at least in part, with dazl (By similarity). Involved in the maternal-to-zygotic transition in early embryo via interaction with ybx1: interaction recruits pabpc1a on C5-methylcytosine (m5C)-containing maternal mRNAs, preventing their degradation. Belongs to the polyadenylate-binding protein type-1 family. | 0.660 |
| ddx61 | rpl6 | ENSDARP00000129311 | ENSDARP00000091899 | DEAD (Asp-Glu-Ala-Asp) box helicase 61; Belongs to the DEAD box helicase family. | Ribosomal protein L6. | 0.462 |
| ddx61 | ybx1 | ENSDARP00000129311 | ENSDARP00000010482 | DEAD (Asp-Glu-Ala-Asp) box helicase 61; Belongs to the DEAD box helicase family. | Y-box-binding protein 1; DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing and transcription regulation. Binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C). Promotes mRNA stabilization: acts by binding to m5C- containing mRNAs and recruiting pabpc1a, thereby preventing mRNA decay. Plays a role in the maternal-to-zygotic transition in early embryo by binding to m5C-containing maternal mRNAs and preventing their degradation. Also [...] | 0.897 |
| nsun2 | alyref | ENSDARP00000118997 | ENSDARP00000139993 | NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Aly/REF export factor. | 0.950 |
| nsun2 | pabpc1a | ENSDARP00000118997 | ENSDARP00000021064 | NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Polyadenylate-binding protein 1A; Binds the poly(A) tail of mRNA (By similarity). Prevents mRNA deadenylation and confers poly(A) stability (By similarity). Stimulates the translation of mRNAs to which it is bound, acting, at least in part, with dazl (By similarity). Involved in the maternal-to-zygotic transition in early embryo via interaction with ybx1: interaction recruits pabpc1a on C5-methylcytosine (m5C)-containing maternal mRNAs, preventing their degradation. Belongs to the polyadenylate-binding protein type-1 family. | 0.684 |
| nsun2 | ybx1 | ENSDARP00000118997 | ENSDARP00000010482 | NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Y-box-binding protein 1; DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing and transcription regulation. Binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C). Promotes mRNA stabilization: acts by binding to m5C- containing mRNAs and recruiting pabpc1a, thereby preventing mRNA decay. Plays a role in the maternal-to-zygotic transition in early embryo by binding to m5C-containing maternal mRNAs and preventing their degradation. Also [...] | 0.905 |
| pabpc1a | alyref | ENSDARP00000021064 | ENSDARP00000139993 | Polyadenylate-binding protein 1A; Binds the poly(A) tail of mRNA (By similarity). Prevents mRNA deadenylation and confers poly(A) stability (By similarity). Stimulates the translation of mRNAs to which it is bound, acting, at least in part, with dazl (By similarity). Involved in the maternal-to-zygotic transition in early embryo via interaction with ybx1: interaction recruits pabpc1a on C5-methylcytosine (m5C)-containing maternal mRNAs, preventing their degradation. Belongs to the polyadenylate-binding protein type-1 family. | Aly/REF export factor. | 0.693 |
| pabpc1a | ddx61 | ENSDARP00000021064 | ENSDARP00000129311 | Polyadenylate-binding protein 1A; Binds the poly(A) tail of mRNA (By similarity). Prevents mRNA deadenylation and confers poly(A) stability (By similarity). Stimulates the translation of mRNAs to which it is bound, acting, at least in part, with dazl (By similarity). Involved in the maternal-to-zygotic transition in early embryo via interaction with ybx1: interaction recruits pabpc1a on C5-methylcytosine (m5C)-containing maternal mRNAs, preventing their degradation. Belongs to the polyadenylate-binding protein type-1 family. | DEAD (Asp-Glu-Ala-Asp) box helicase 61; Belongs to the DEAD box helicase family. | 0.660 |
| pabpc1a | nsun2 | ENSDARP00000021064 | ENSDARP00000118997 | Polyadenylate-binding protein 1A; Binds the poly(A) tail of mRNA (By similarity). Prevents mRNA deadenylation and confers poly(A) stability (By similarity). Stimulates the translation of mRNAs to which it is bound, acting, at least in part, with dazl (By similarity). Involved in the maternal-to-zygotic transition in early embryo via interaction with ybx1: interaction recruits pabpc1a on C5-methylcytosine (m5C)-containing maternal mRNAs, preventing their degradation. Belongs to the polyadenylate-binding protein type-1 family. | NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | 0.684 |
| pabpc1a | rpl6 | ENSDARP00000021064 | ENSDARP00000091899 | Polyadenylate-binding protein 1A; Binds the poly(A) tail of mRNA (By similarity). Prevents mRNA deadenylation and confers poly(A) stability (By similarity). Stimulates the translation of mRNAs to which it is bound, acting, at least in part, with dazl (By similarity). Involved in the maternal-to-zygotic transition in early embryo via interaction with ybx1: interaction recruits pabpc1a on C5-methylcytosine (m5C)-containing maternal mRNAs, preventing their degradation. Belongs to the polyadenylate-binding protein type-1 family. | Ribosomal protein L6. | 0.753 |
| pabpc1a | ybx1 | ENSDARP00000021064 | ENSDARP00000010482 | Polyadenylate-binding protein 1A; Binds the poly(A) tail of mRNA (By similarity). Prevents mRNA deadenylation and confers poly(A) stability (By similarity). Stimulates the translation of mRNAs to which it is bound, acting, at least in part, with dazl (By similarity). Involved in the maternal-to-zygotic transition in early embryo via interaction with ybx1: interaction recruits pabpc1a on C5-methylcytosine (m5C)-containing maternal mRNAs, preventing their degradation. Belongs to the polyadenylate-binding protein type-1 family. | Y-box-binding protein 1; DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing and transcription regulation. Binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C). Promotes mRNA stabilization: acts by binding to m5C- containing mRNAs and recruiting pabpc1a, thereby preventing mRNA decay. Plays a role in the maternal-to-zygotic transition in early embryo by binding to m5C-containing maternal mRNAs and preventing their degradation. Also [...] | 0.874 |
| rpl6 | ddx61 | ENSDARP00000091899 | ENSDARP00000129311 | Ribosomal protein L6. | DEAD (Asp-Glu-Ala-Asp) box helicase 61; Belongs to the DEAD box helicase family. | 0.462 |
| rpl6 | pabpc1a | ENSDARP00000091899 | ENSDARP00000021064 | Ribosomal protein L6. | Polyadenylate-binding protein 1A; Binds the poly(A) tail of mRNA (By similarity). Prevents mRNA deadenylation and confers poly(A) stability (By similarity). Stimulates the translation of mRNAs to which it is bound, acting, at least in part, with dazl (By similarity). Involved in the maternal-to-zygotic transition in early embryo via interaction with ybx1: interaction recruits pabpc1a on C5-methylcytosine (m5C)-containing maternal mRNAs, preventing their degradation. Belongs to the polyadenylate-binding protein type-1 family. | 0.753 |
