node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
JMY | tp53 | ENSDARP00000152926 | ENSDARP00000116736 | Junction mediating and regulatory protein, p53 cofactor. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. | 0.580 |
JMY | tp53bp2a | ENSDARP00000152926 | ENSDARP00000010764 | Junction mediating and regulatory protein, p53 cofactor. | Tumor protein p53-binding protein, 2a. | 0.701 |
TP53I3 | rnf25 | ENSDARP00000144288 | ENSDARP00000038815 | Tumor protein p53 inducible protein 3. | Ring finger protein 25. | 0.645 |
TP53I3 | tp53bp2a | ENSDARP00000144288 | ENSDARP00000010764 | Tumor protein p53 inducible protein 3. | Tumor protein p53-binding protein, 2a. | 0.568 |
btf3l4 | spag8 | ENSDARP00000137039 | ENSDARP00000138588 | Transcription factor BTF3 homolog 4; Belongs to the NAC-beta family. | Sperm-associated antigen 8. | 0.662 |
btf3l4 | tp53bp2a | ENSDARP00000137039 | ENSDARP00000010764 | Transcription factor BTF3 homolog 4; Belongs to the NAC-beta family. | Tumor protein p53-binding protein, 2a. | 0.558 |
gart | tp53bp2a | ENSDARP00000131447 | ENSDARP00000010764 | Phosphoribosylglycinamide formyltransferase. | Tumor protein p53-binding protein, 2a. | 0.591 |
ppp1caa | tp53bp2a | ENSDARP00000002360 | ENSDARP00000010764 | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. | Tumor protein p53-binding protein, 2a. | 0.513 |
rnf25 | TP53I3 | ENSDARP00000038815 | ENSDARP00000144288 | Ring finger protein 25. | Tumor protein p53 inducible protein 3. | 0.645 |
rnf25 | tp53bp2a | ENSDARP00000038815 | ENSDARP00000010764 | Ring finger protein 25. | Tumor protein p53-binding protein, 2a. | 0.549 |
spag8 | btf3l4 | ENSDARP00000138588 | ENSDARP00000137039 | Sperm-associated antigen 8. | Transcription factor BTF3 homolog 4; Belongs to the NAC-beta family. | 0.662 |
spag8 | tp53bp2a | ENSDARP00000138588 | ENSDARP00000010764 | Sperm-associated antigen 8. | Tumor protein p53-binding protein, 2a. | 0.569 |
tp53 | JMY | ENSDARP00000116736 | ENSDARP00000152926 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. | Junction mediating and regulatory protein, p53 cofactor. | 0.580 |
tp53 | tp53bp2a | ENSDARP00000116736 | ENSDARP00000010764 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. | Tumor protein p53-binding protein, 2a. | 0.848 |
tp53 | tp63 | ENSDARP00000116736 | ENSDARP00000065136 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. | 0.769 |
tp53 | tp73 | ENSDARP00000116736 | ENSDARP00000109674 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.768 |
tp53bp2a | JMY | ENSDARP00000010764 | ENSDARP00000152926 | Tumor protein p53-binding protein, 2a. | Junction mediating and regulatory protein, p53 cofactor. | 0.701 |
tp53bp2a | TP53I3 | ENSDARP00000010764 | ENSDARP00000144288 | Tumor protein p53-binding protein, 2a. | Tumor protein p53 inducible protein 3. | 0.568 |
tp53bp2a | btf3l4 | ENSDARP00000010764 | ENSDARP00000137039 | Tumor protein p53-binding protein, 2a. | Transcription factor BTF3 homolog 4; Belongs to the NAC-beta family. | 0.558 |
tp53bp2a | gart | ENSDARP00000010764 | ENSDARP00000131447 | Tumor protein p53-binding protein, 2a. | Phosphoribosylglycinamide formyltransferase. | 0.591 |