| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| jag1a | jag1b | ENSDARP00000121170 | ENSDARP00000008197 | Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | Protein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | 0.830 |
| jag1a | jag2b | ENSDARP00000121170 | ENSDARP00000010799 | Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | 0.830 |
| jag1a | maml1 | ENSDARP00000121170 | ENSDARP00000102289 | Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | Mastermind-like transcriptional coactivator 1. | 0.866 |
| jag1a | maml3 | ENSDARP00000121170 | ENSDARP00000115500 | Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | Mastermind-like transcriptional coactivator 3. | 0.851 |
| jag1a | mib1 | ENSDARP00000121170 | ENSDARP00000132570 | Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] | 0.851 |
| jag1a | notch1a | ENSDARP00000121170 | ENSDARP00000137942 | Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.967 |
| jag1a | notch1b | ENSDARP00000121170 | ENSDARP00000050854 | Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | Notch receptor 1b. | 0.956 |
| jag1a | notch2 | ENSDARP00000121170 | ENSDARP00000112112 | Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | Notch receptor 2. | 0.909 |
| jag1a | notch3 | ENSDARP00000121170 | ENSDARP00000068420 | Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | Notch receptor 3. | 0.950 |
| jag1a | zmp:0000001236 | ENSDARP00000121170 | ENSDARP00000151452 | Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | MamL-1 domain-containing protein. | 0.849 |
| jag1b | jag1a | ENSDARP00000008197 | ENSDARP00000121170 | Protein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | 0.830 |
| jag1b | jag2b | ENSDARP00000008197 | ENSDARP00000010799 | Protein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | 0.830 |
| jag1b | maml1 | ENSDARP00000008197 | ENSDARP00000102289 | Protein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | Mastermind-like transcriptional coactivator 1. | 0.824 |
| jag1b | maml3 | ENSDARP00000008197 | ENSDARP00000115500 | Protein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | Mastermind-like transcriptional coactivator 3. | 0.820 |
| jag1b | mib1 | ENSDARP00000008197 | ENSDARP00000132570 | Protein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] | 0.818 |
| jag1b | notch1a | ENSDARP00000008197 | ENSDARP00000137942 | Protein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.969 |
| jag1b | notch1b | ENSDARP00000008197 | ENSDARP00000050854 | Protein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | Notch receptor 1b. | 0.953 |
| jag1b | notch2 | ENSDARP00000008197 | ENSDARP00000112112 | Protein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | Notch receptor 2. | 0.871 |
| jag1b | notch3 | ENSDARP00000008197 | ENSDARP00000068420 | Protein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | Notch receptor 3. | 0.942 |
| jag1b | zmp:0000001236 | ENSDARP00000008197 | ENSDARP00000151452 | Protein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | MamL-1 domain-containing protein. | 0.815 |
