Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ube2e3Ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family. (209 aa)    
Predicted Functional Partners:
ube2e2
Ubiquitin-conjugating enzyme E2E 2; Belongs to the ubiquitin-conjugating enzyme family.
  
 
0.929
gcdhb
Glutaryl-CoA dehydrogenase b.
 
  
   0.901
gcdha
Glutaryl-Coenzyme A dehydrogenase.
 
  
   0.900
ube2e1
Ubiquitin-conjugating enzyme E2E 1; Belongs to the ubiquitin-conjugating enzyme family.
     
  0.849
ube2v2
Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The ube2v2/ube2n heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity); Belongs to the ubiquitin-c [...]
   
 0.844
trip12
E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spr [...]
    
 
 0.841
UBA6
Si:dkey-82j4.2.
   
 0.839
ube2v1
Ubiquitin-conjugating enzyme E2 variant 1.
   
 0.799
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
   
 0.780
stub1
STIP1 homology and U-Box-containing protein 1.
   
 
 0.755
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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