Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
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[Homology]
Score
hmx4H6 family homeobox 4. (238 aa)    
Predicted Functional Partners:
cpz
Carboxypeptidase Z.
      
 0.594
six6b
Sine oculis-related homeobox 6b.
   
  
 0.556
isy1
ISY1-splicing factor homolog.
    
   0.531
ppp1r21
Protein phosphatase 1 regulatory subunit 21; Putative regulator of protein phosphatase 1 (PP1) activity. May play a role in the endosomal sorting process or in endosome maturation pathway.
    
   0.531
prox2
Prospero homeobox 2.
      
 0.517
stx3a
Syntaxin 3A; Belongs to the syntaxin family.
      
 0.504
m1ap
Meiosis 1-associated protein.
      
 0.504
pax6b
Paired box 6b.
   
 
 0.495
tbx1
T-box transcription factor TBX1; May act as a transcriptional factor. Acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily.
    
 
 0.490
impdh1b
Inosine-5'-monophosphate dehydrogenase 1b; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
      
 0.489
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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