Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
dohhDeoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF- 5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. (305 aa)    
Predicted Functional Partners:
dhps
Deoxyhypusine synthase.
   
 0.999
eif5a2
Eukaryotic translation initiation factor 5A.
  
 0.996
eif5a
Eukaryotic translation initiation factor 5A.
  
 0.996
sms
Spermine synthase.
   
  
 0.873
srm
Spermidine synthase; Belongs to the spermidine/spermine synthase family.
   
  
 0.864
znf593
Zinc finger protein 593.
   
  
 0.831
amd1
S-adenosylmethionine decarboxylase proenzyme.
   
  
 0.786
grwd1
Glutamate-rich WD repeat-containing 1.
   
  
 0.782
gpd2
Glycerol-3-phosphate dehydrogenase 2 (mitochondrial).
     
 0.771
atic
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.
  
 
  0.768
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (18%) [HD]