Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ppm1bbProtein phosphatase 1A, magnesium dependent, alpha isoform. (382 aa)    
Predicted Functional Partners:
map3k7
Mitogen-activated protein kinase kinase kinase 7.
   
 0.948
ppm1ba
Protein phosphatase, Mg2+/Mn2+-dependent, 1Ba.
     
  0.934
ranbp3a
RAN-binding protein 3a.
    
 
 0.704
map2k6
Dual specificity mitogen-activated protein kinase kinase 6; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Phosphorylation by MAP2K6 asymmetrically activates p38 on one side of the blastodisc, an event which is n [...]
    
 0.695
map2k7
Mitogen-activated protein kinase kinase 7.
   
  0.687
ppm1nb
Protein phosphatase, Mg2+/Mn2+-dependent, 1Nb (putative).
     
  0.640
map2k4b
Mitogen-activated protein kinase kinase 4B; Belongs to the protein kinase superfamily.
    
 0.583
map2k4a
Mitogen-activated protein kinase kinase 4A; Belongs to the protein kinase superfamily.
    
 0.583
mynn
Myoneurin.
    
 0.574
slc3a1
Solute carrier family 3 member 1.
 
 
  
 0.521
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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