Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
krt1-19dKeratin, type 1, gene 19d; Belongs to the intermediate filament family. (423 aa)    
Predicted Functional Partners:
krt5
Keratin 5; Belongs to the intermediate filament family.
   
0.792
iffo2a
Intermediate filament family orphan 2a; Belongs to the intermediate filament family.
      
 0.780
iffo2b
Intermediate filament family orphan 2b; Belongs to the intermediate filament family.
      
 0.737
zgc:158846
Zgc:158846; Belongs to the intermediate filament family.
  
0.731
iffo1b
Intermediate filament family orphan 1b; Belongs to the intermediate filament family.
      
 0.718
krt4
Keratin 4; Belongs to the intermediate filament family.
  
0.698
krt8
Keratin, type II cytoskeletal 8; Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
  
 
 
0.669
cldnh
Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
   
 0.666
cldni
Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
   
 0.655
F1RDG4_DANRE
Si:dkey-222f2.1; Belongs to the intermediate filament family.
  
 
0.637
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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