Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
flot2aFlotillin-2a; May play a role in axon growth and regeneration. May be involved in epidermal cell adhesion and epidermal structure and function (By similarity). (428 aa)    
Predicted Functional Partners:
flot1a
Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.
  
  
0.987
flot1b
Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.
  
 
0.975
sorbs1
Sorbin and SH3 domain-containing 1.
    
  0.914
flot2b
Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.
  
  
 
0.900
sorbs2a
Sorbin and SH3 domain-containing 2a.
    
  0.806
sorbs2b
Sorbin and SH3 domain-containing 2b.
    
  0.806
ap2m1a
AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]
   
  
 0.745
cav3
Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.
    
 
 0.722
ldlrap1b
Low density lipoprotein receptor adaptor protein 1b.
      
 0.680
cav2
Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.
   
 
 0.663
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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