STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ddi2Protein DDI1 homolog 2; Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane. Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1. Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2. Required for cellular survival following replication stress. Belongs to the DDI1 family. (411 aa)    
Predicted Functional Partners:
rps27a
Ribosomal protein S27a.
   
 
 0.808
ubc
Ubiquitin C.
   
 
 0.732
ubb
Ubiquitin B.
   
 
 0.732
psmd14
Proteasome 26S subunit, non-ATPase 14.
   
 
 0.709
UBB
Si:ch211-202a12.4.
   
 
 0.708
rad23ab
RAD23 homolog A, nucleotide excision repair protein b.
   
 
 0.661
rad23aa
RAD23 homolog A, nucleotide excision repair protein a.
   
 
 0.661
rad23b
RAD23 homolog B, nucleotide excision repair protein.
   
 
 0.661
ubqln4
Ubiquilin 4.
   
 
 0.651
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
   
   0.626
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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