msrb2 protein (Danio rerio) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

msrb2

Methionine-R-sulfoxide reductase B2, mitochondrial; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maint [...] (184 aa)

Predicted Functional Partners:

hoga1

0.699

TXN

0.696

F1R878_DANRE

0.674

msra

0.659

sephs2

0.636

selenof

0.621

bcl2l13

0.605

glrx2

0.597

atp5meb

0.578

mboat7

0.567

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F1R878_DANRE	TXN	ENSDARP00000072074	ENSDARP00000045696	Si:ch1073-358c10.1.	Thioredoxin; Belongs to the thioredoxin family.	0.726
F1R878_DANRE	glrx2	ENSDARP00000072074	ENSDARP00000136884	Si:ch1073-358c10.1.	Glutaredoxin 2.	0.455
F1R878_DANRE	msrb2	ENSDARP00000072074	ENSDARP00000012146	Si:ch1073-358c10.1.	Methionine-R-sulfoxide reductase B2, mitochondrial; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maint [...]	0.674
TXN	F1R878_DANRE	ENSDARP00000045696	ENSDARP00000072074	Thioredoxin; Belongs to the thioredoxin family.	Si:ch1073-358c10.1.	0.726
TXN	glrx2	ENSDARP00000045696	ENSDARP00000136884	Thioredoxin; Belongs to the thioredoxin family.	Glutaredoxin 2.	0.886
TXN	msra	ENSDARP00000045696	ENSDARP00000047361	Thioredoxin; Belongs to the thioredoxin family.	Methionine sulfoxide reductase A.	0.916
TXN	msrb2	ENSDARP00000045696	ENSDARP00000012146	Thioredoxin; Belongs to the thioredoxin family.	Methionine-R-sulfoxide reductase B2, mitochondrial; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maint [...]	0.696
TXN	selenof	ENSDARP00000045696	ENSDARP00000137608	Thioredoxin; Belongs to the thioredoxin family.	Selenoprotein F; May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum (By similarity).	0.618
TXN	sephs2	ENSDARP00000045696	ENSDARP00000026731	Thioredoxin; Belongs to the thioredoxin family.	Selenophosphate synthetase 2.	0.684
atp5meb	hoga1	ENSDARP00000090664	ENSDARP00000021126	ATP synthase membrane subunit eb.	4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Catalyzes the final step in the metabolic pathway of hydroxyproline.	0.723
atp5meb	msrb2	ENSDARP00000090664	ENSDARP00000012146	ATP synthase membrane subunit eb.	Methionine-R-sulfoxide reductase B2, mitochondrial; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maint [...]	0.578
bcl2l13	msrb2	ENSDARP00000120878	ENSDARP00000012146	Bcl2l13 protein.	Methionine-R-sulfoxide reductase B2, mitochondrial; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maint [...]	0.605
glrx2	F1R878_DANRE	ENSDARP00000136884	ENSDARP00000072074	Glutaredoxin 2.	Si:ch1073-358c10.1.	0.455
glrx2	TXN	ENSDARP00000136884	ENSDARP00000045696	Glutaredoxin 2.	Thioredoxin; Belongs to the thioredoxin family.	0.886
glrx2	msra	ENSDARP00000136884	ENSDARP00000047361	Glutaredoxin 2.	Methionine sulfoxide reductase A.	0.455
glrx2	msrb2	ENSDARP00000136884	ENSDARP00000012146	Glutaredoxin 2.	Methionine-R-sulfoxide reductase B2, mitochondrial; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maint [...]	0.597
hoga1	atp5meb	ENSDARP00000021126	ENSDARP00000090664	4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Catalyzes the final step in the metabolic pathway of hydroxyproline.	ATP synthase membrane subunit eb.	0.723
hoga1	msrb2	ENSDARP00000021126	ENSDARP00000012146	4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Catalyzes the final step in the metabolic pathway of hydroxyproline.	Methionine-R-sulfoxide reductase B2, mitochondrial; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maint [...]	0.699
mboat7	msrb2	ENSDARP00000047569	ENSDARP00000012146	Lysophospholipid acyltransferase 7; Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.	Methionine-R-sulfoxide reductase B2, mitochondrial; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maint [...]	0.567
msra	TXN	ENSDARP00000047361	ENSDARP00000045696	Methionine sulfoxide reductase A.	Thioredoxin; Belongs to the thioredoxin family.	0.916

page 1 of 2

Server load: low (20%) [HD]

Permalink

Network

Neighborhood

Experiments

Co-occurrence

Databases

Co-expression

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About