Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
dnase1l4.2Deoxyribonuclease; Belongs to the DNase I family. (282 aa)    
Predicted Functional Partners:
ikbke
Inhibitor of nuclear factor kappa B kinase subunit epsilon.
   
 0.719
tbk1
TANK-binding kinase 1.
   
 0.719
tnfb
Tumor necrosis factor b (TNF superfamily, member 2).
    
 
 0.675
ikbkg
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
    
 0.670
azi2
5-azacytidine-induced 2.
   
 
 0.652
nudt12
Nudix (nucleoside diphosphate-linked moiety X)-type motif 12.
    
 0.621
tbkbp1
TBK1-binding protein 1.
     
 0.618
trpm2
Transient receptor potential cation channel subfamily M member 2; Nonselective, voltage-independent cation channel that mediates Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as ligand-gated ion channel. Binding of ADP-ribose to the cytoplasmic N-terminal region causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily.
     
  0.606
tradd
Tumor necrosis factor receptor type 1-associated DEATH domain protein; Adapter molecule for tnfrsf1a that specifically associates with the cytoplasmic domain of activated tnfrsf1a mediating its interaction with fadd.
     
 0.536
mib2
Mindbomb E3 ubiquitin protein ligase 2.
    
 0.528
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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